Dr Benjamin Housden Associate Professor B.Housden@exeter.ac.uk CMH Groups: Housden Group University profile 0000-0001-9134-4279 Publications Publications 2021 Synthetic lethal screening identifies existing autophagy drugs with selective viability effects on Neurofibromatosis type-1 model systems Published: 30/11/2021 PPR: PPR434701 DOI: 10.1101/2021.12.20.473481 URL: http://europepmc.org/abstract/PPR/PPR434701 Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis. Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 31/08/2021 PMID: 34521754 PMC: PMC8463893 DOI: 10.1073/pnas.2108874118 URL: http://europepmc.org/abstract/med/34521754 Characterization of the RNA-interference pathway as a tool for reverse genetic analysis in the nascent phototrophic endosymbiosis, Paramecium bursaria. Journal: Royal Society open science Published: 31/03/2021 PMID: 33996132 PMC: PMC8059543 DOI: 10.1098/rsos.210140 URL: http://europepmc.org/abstract/med/33996132 Emergent RNA-RNA interactions can promote stability in a nascent phototrophic endosymbiosis Published: 31/03/2021 PPR: PPR310038 DOI: 10.1101/2021.04.11.439338 URL: http://europepmc.org/abstract/PPR/PPR310038 2020 Characterisation of the RNA-interference pathway as a Tool for Genetics in the Nascent Phototrophic Endosymbiosis, Paramecium bursaria Published: 30/11/2020 PPR: PPR272496 DOI: 10.1101/2020.12.16.423098 URL: http://europepmc.org/abstract/PPR/PPR272496 2019 HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species. Journal: Science signaling Published: 30/09/2019 PMID: 31575731 PMC: PMC6913182 DOI: 10.1126/scisignal.aay0482 URL: http://europepmc.org/abstract/med/31575731 Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos. Published: 31/07/2019 PPR: PPR88386 DOI: 10.1101/728899 URL: http://europepmc.org/abstract/PPR/PPR88386 2018 The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Journal: Cell reports Published: 31/12/2018 PMID: 30650359 PMC: PMC6394833 DOI: 10.1016/j.celrep.2018.12.079 URL: http://europepmc.org/abstract/med/30650359 Variable Dose Analysis: A Novel High-throughput RNAi Screening Method for Drosophila Cells. Journal: Bio-protocol Published: 30/11/2018 PMID: 34532554 PMC: PMC8342101 DOI: 10.21769/bioprotoc.3112 URL: http://europepmc.org/abstract/med/34532554 A gene-specific T2A-GAL4 library for Drosophila. Journal: eLife Published: 28/02/2018 PMID: 29565247 PMC: PMC5898912 DOI: 10.7554/elife.35574 URL: http://europepmc.org/abstract/med/29565247 2017 Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 31/10/2017 PMID: 29183982 DOI: 10.1073/pnas.1713362114 URL: http://europepmc.org/abstract/med/29183982 mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Journal: Cancer cell Published: 31/10/2017 PMID: 29056426 DOI: 10.1016/j.ccell.2017.09.013 URL: http://europepmc.org/abstract/med/29056426 A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Journal: Developmental cell Published: 30/09/2017 PMID: 29017032 DOI: 10.1016/j.devcel.2017.09.007 URL: http://europepmc.org/abstract/med/29017032 Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells. Published: 31/07/2017 PPR: PPR20558 DOI: 10.1101/179598 URL: http://europepmc.org/abstract/PPR/PPR20558 Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions Published: 31/07/2017 PPR: PPR25750 DOI: 10.1101/176974 URL: http://europepmc.org/abstract/PPR/PPR25750 Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells Journal: Bio-protocol Published: 05/02/2017 PMID: 28523286 URL: 2016 Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Published: 31/12/2016 PMID: 27795562 DOI: 10.1038/nrg.2016.118 URL: http://europepmc.org/abstract/med/27795562 Compositions and methods for inhibiting cell proliferation Published: 30/09/2016 URL: https://www.google.com/patents/WO2016141297A3?cl=un CRISPR guide RNA design for research applications. Published: 31/08/2016 PMID: 27276584 PMC: PMC5014588 DOI: 10.1111/febs.13777 URL: http://europepmc.org/abstract/med/27276584 Mapping signaling pathway cross-talk in Drosophila cells. Published: 31/07/2016 PMID: 27528688 DOI: 10.1073/pnas.1610432113 URL: http://europepmc.org/abstract/med/27528688 Seipin is required for converting nascent to mature lipid droplets. Published: 31/07/2016 PMID: 27564575 PMC: PMC5035145 DOI: 10.7554/elife.16582 URL: http://europepmc.org/abstract/med/27564575 Comparison of Cas9 activators in multiple species. Published: 30/06/2016 PMID: 27214048 PMC: PMC4927356 DOI: 10.1038/nmeth.3871 URL: http://europepmc.org/abstract/med/27214048 Comparing CRISPR and RNAi-based screening technologies. Published: 31/05/2016 PMID: 27281421 DOI: 10.1038/nbt.3599 URL: http://europepmc.org/abstract/med/27281421 2015 Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours. Published: 31/12/2015 PMID: 26657768 PMC: PMC4725341 DOI: 10.1242/dev.126326 URL: http://europepmc.org/abstract/med/26657768 Cas9-Mediated Genome Engineering in Drosophila melanogaster. Published: 30/11/2015 PMID: 27587786 DOI: 10.1101/pdb.top086843 URL: http://europepmc.org/abstract/med/27587786 Design and Generation of Donor Constructs for Genome Engineering in Drosophila. Published: 30/11/2015 PMID: 27587780 DOI: 10.1101/pdb.prot090787 URL: http://europepmc.org/abstract/med/27587780 Design and Generation of Drosophila Single Guide RNA Expression Constructs. Published: 30/11/2015 PMID: 27587779 DOI: 10.1101/pdb.prot090779 URL: http://europepmc.org/abstract/med/27587779 Detection of Indel Mutations in Drosophila by High-Resolution Melt Analysis (HRMA). Published: 30/11/2015 PMID: 27587781 DOI: 10.1101/pdb.prot090795 URL: http://europepmc.org/abstract/med/27587781 In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila. Published: 30/09/2015 PMID: 26245833 PMC: PMC4596659 DOI: 10.1534/genetics.115.181065 URL: http://europepmc.org/abstract/med/26245833 Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Published: 31/08/2015 PMID: 26350902 PMC: PMC4642709 DOI: 10.1126/scisignal.aab3729 URL: http://europepmc.org/abstract/med/26350902 Highly efficient Cas9-mediated transcriptional programming. Published: 31/03/2015 PMID: 25730490 PMC: PMC4393883 DOI: 10.1038/nmeth.3312 URL: http://europepmc.org/abstract/med/25730490 2014 Drosophila p53 controls Notch expression and balances apoptosis and proliferation. Published: 30/09/2014 PMID: 24858703 DOI: 10.1007/s10495-014-1000-5 URL: http://europepmc.org/abstract/med/24858703 Spatial and temporal organization of signaling pathways. Published: 30/09/2014 PMID: 25155749 PMC: PMC4477539 DOI: 10.1016/j.tibs.2014.07.008 URL: http://europepmc.org/abstract/med/25155749 Resources for functional genomics studies in Drosophila melanogaster. Published: 30/04/2014 PMID: 24653003 PMC: PMC4012471 DOI: 10.1534/genetics.113.154344 URL: http://europepmc.org/abstract/med/24653003 Context-dependent enhancer selection confers alternate modes of notch regulation on argos. Published: 31/01/2014 PMID: 24324007 PMC: PMC3911485 DOI: 10.1128/mcb.01045-13 URL: http://europepmc.org/abstract/med/24324007 2013 Cas9-based genome editing in Drosophila. Published: 30/11/2013 PMID: 25398351 DOI: 10.1016/b978-0-12-801185-0.00019-2 URL: http://europepmc.org/abstract/med/25398351 Notch signaling assays in Drosophila cultured cell lines. Published: 30/11/2013 PMID: 25053486 DOI: 10.1007/978-1-4939-1139-4_10 URL: http://europepmc.org/abstract/med/25053486 Visualizing Notch signaling in vivo in Drosophila tissues. Published: 30/11/2013 PMID: 25053484 DOI: 10.1007/978-1-4939-1139-4_8 URL: http://europepmc.org/abstract/med/25053484 Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Published: 31/10/2013 PMID: 24191015 PMC: PMC3839733 DOI: 10.1073/pnas.1318481110 URL: http://europepmc.org/abstract/med/24191015 2012 Deadpan contributes to the robustness of the notch response. Published: 30/11/2012 PMID: 24086596 PMC: PMC3782438 DOI: 10.1371/journal.pone.0075632 URL: http://europepmc.org/abstract/med/24086596 Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. Published: 30/11/2012 PMID: 23300480 PMC: PMC3536677 DOI: 10.1371/journal.pgen.1003162 URL: http://europepmc.org/abstract/med/23300480 2011 Drosophila Reporter Vectors Compatible with ΦC31 Integrase Transgenesis Techniques and Their Use to Generate New Notch Reporter Fly Lines. Published: 31/12/2011 PMID: 22384384 PMC: PMC3276196 DOI: 10.1534/g3.111.001321 URL: http://europepmc.org/abstract/med/22384384 2010 Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Published: 31/07/2010 PMID: 20610485 PMC: PMC2910383 DOI: 10.1242/dev.053181 URL: http://europepmc.org/abstract/med/20610485 The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. Published: 28/02/2010 PMID: 20150280 PMC: PMC2834460 DOI: 10.1242/dev.043224 URL: http://europepmc.org/abstract/med/20150280 2008 Direct response to Notch activation: signaling crosstalk and incoherent logic. Published: 31/12/2008 PMID: 19176515 DOI: 10.1126/scisignal.2000140 URL: http://europepmc.org/abstract/med/19176515