Publications
2021
Synthetic lethal screening identifies existing autophagy drugs with selective viability effects on Neurofibromatosis type-1 model systems
Published: 30/11/2021PPR: PPR434701
DOI: 10.1101/2021.12.20.473481
URL: http://europepmc.org/abstract/PPR/PPR434701
Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis.
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Published:
31/08/2021
PMID: 34521754
PMC: PMC8463893
DOI: 10.1073/pnas.2108874118
URL: http://europepmc.org/abstract/med/34521754
Characterization of the RNA-interference pathway as a tool for reverse genetic analysis in the nascent phototrophic endosymbiosis, Paramecium bursaria.
Journal:
Royal Society open science
Published:
31/03/2021
PMID: 33996132
PMC: PMC8059543
DOI: 10.1098/rsos.210140
URL: http://europepmc.org/abstract/med/33996132
Emergent RNA-RNA interactions can promote stability in a nascent phototrophic endosymbiosis
Published: 31/03/2021PPR: PPR310038
DOI: 10.1101/2021.04.11.439338
URL: http://europepmc.org/abstract/PPR/PPR310038
2020
Characterisation of the RNA-interference pathway as a Tool for Genetics in the Nascent Phototrophic Endosymbiosis, Paramecium bursaria
Published: 30/11/2020PPR: PPR272496
DOI: 10.1101/2020.12.16.423098
URL: http://europepmc.org/abstract/PPR/PPR272496
2019
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.
Journal:
Science signaling
Published:
30/09/2019
PMID: 31575731
PMC: PMC6913182
DOI: 10.1126/scisignal.aay0482
URL: http://europepmc.org/abstract/med/31575731
Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.
Published: 31/07/2019PPR: PPR88386
DOI: 10.1101/728899
URL: http://europepmc.org/abstract/PPR/PPR88386
2018
The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling.
Journal:
Cell reports
Published:
31/12/2018
PMID: 30650359
PMC: PMC6394833
DOI: 10.1016/j.celrep.2018.12.079
URL: http://europepmc.org/abstract/med/30650359
Variable Dose Analysis: A Novel High-throughput RNAi Screening Method for Drosophila Cells.
Journal:
Bio-protocol
Published:
30/11/2018
PMID: 34532554
PMC: PMC8342101
DOI: 10.21769/bioprotoc.3112
URL: http://europepmc.org/abstract/med/34532554
A gene-specific T2A-GAL4 library for Drosophila.
Journal:
eLife
Published:
28/02/2018
PMID: 29565247
PMC: PMC5898912
DOI: 10.7554/elife.35574
URL: http://europepmc.org/abstract/med/29565247
2017
Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Published:
31/10/2017
PMID: 29183982
DOI: 10.1073/pnas.1713362114
URL: http://europepmc.org/abstract/med/29183982
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.
Journal:
Cancer cell
Published:
31/10/2017
PMID: 29056426
DOI: 10.1016/j.ccell.2017.09.013
URL: http://europepmc.org/abstract/med/29056426
A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion.
Journal:
Developmental cell
Published:
30/09/2017
PMID: 29017032
DOI: 10.1016/j.devcel.2017.09.007
URL: http://europepmc.org/abstract/med/29017032
Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells.
Published: 31/07/2017PPR: PPR20558
DOI: 10.1101/179598
URL: http://europepmc.org/abstract/PPR/PPR20558
Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions
Published: 31/07/2017PPR: PPR25750
DOI: 10.1101/176974
URL: http://europepmc.org/abstract/PPR/PPR25750
Synthetic Lethality Screens Using RNAi in Combination with CRISPR-based Knockout in Drosophila Cells
Journal:
Bio-protocol
Published:
05/02/2017
PMID: 28523286
URL:
2016
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.
Published: 31/12/2016PMID: 27795562
DOI: 10.1038/nrg.2016.118
URL: http://europepmc.org/abstract/med/27795562
Compositions and methods for inhibiting cell proliferation
Published: 30/09/2016URL: https://www.google.com/patents/WO2016141297A3?cl=un
CRISPR guide RNA design for research applications.
Published: 31/08/2016PMID: 27276584
PMC: PMC5014588
DOI: 10.1111/febs.13777
URL: http://europepmc.org/abstract/med/27276584
Mapping signaling pathway cross-talk in Drosophila cells.
Published: 31/07/2016PMID: 27528688
DOI: 10.1073/pnas.1610432113
URL: http://europepmc.org/abstract/med/27528688
Seipin is required for converting nascent to mature lipid droplets.
Published: 31/07/2016PMID: 27564575
PMC: PMC5035145
DOI: 10.7554/elife.16582
URL: http://europepmc.org/abstract/med/27564575
Comparison of Cas9 activators in multiple species.
Published: 30/06/2016PMID: 27214048
PMC: PMC4927356
DOI: 10.1038/nmeth.3871
URL: http://europepmc.org/abstract/med/27214048
Comparing CRISPR and RNAi-based screening technologies.
Published: 31/05/2016PMID: 27281421
DOI: 10.1038/nbt.3599
URL: http://europepmc.org/abstract/med/27281421
2015
Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours.
Published: 31/12/2015PMID: 26657768
PMC: PMC4725341
DOI: 10.1242/dev.126326
URL: http://europepmc.org/abstract/med/26657768
Cas9-Mediated Genome Engineering in Drosophila melanogaster.
Published: 30/11/2015PMID: 27587786
DOI: 10.1101/pdb.top086843
URL: http://europepmc.org/abstract/med/27587786
Design and Generation of Donor Constructs for Genome Engineering in Drosophila.
Published: 30/11/2015PMID: 27587780
DOI: 10.1101/pdb.prot090787
URL: http://europepmc.org/abstract/med/27587780
Design and Generation of Drosophila Single Guide RNA Expression Constructs.
Published: 30/11/2015PMID: 27587779
DOI: 10.1101/pdb.prot090779
URL: http://europepmc.org/abstract/med/27587779
Detection of Indel Mutations in Drosophila by High-Resolution Melt Analysis (HRMA).
Published: 30/11/2015PMID: 27587781
DOI: 10.1101/pdb.prot090795
URL: http://europepmc.org/abstract/med/27587781
In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila.
Published: 30/09/2015PMID: 26245833
PMC: PMC4596659
DOI: 10.1534/genetics.115.181065
URL: http://europepmc.org/abstract/med/26245833
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.
Published: 31/08/2015PMID: 26350902
PMC: PMC4642709
DOI: 10.1126/scisignal.aab3729
URL: http://europepmc.org/abstract/med/26350902
Highly efficient Cas9-mediated transcriptional programming.
Published: 31/03/2015PMID: 25730490
PMC: PMC4393883
DOI: 10.1038/nmeth.3312
URL: http://europepmc.org/abstract/med/25730490
2014
Drosophila p53 controls Notch expression and balances apoptosis and proliferation.
Published: 30/09/2014PMID: 24858703
DOI: 10.1007/s10495-014-1000-5
URL: http://europepmc.org/abstract/med/24858703
Spatial and temporal organization of signaling pathways.
Published: 30/09/2014PMID: 25155749
PMC: PMC4477539
DOI: 10.1016/j.tibs.2014.07.008
URL: http://europepmc.org/abstract/med/25155749
Resources for functional genomics studies in Drosophila melanogaster.
Published: 30/04/2014PMID: 24653003
PMC: PMC4012471
DOI: 10.1534/genetics.113.154344
URL: http://europepmc.org/abstract/med/24653003
Context-dependent enhancer selection confers alternate modes of notch regulation on argos.
Published: 31/01/2014PMID: 24324007
PMC: PMC3911485
DOI: 10.1128/mcb.01045-13
URL: http://europepmc.org/abstract/med/24324007
2013
Cas9-based genome editing in Drosophila.
Published: 30/11/2013PMID: 25398351
DOI: 10.1016/b978-0-12-801185-0.00019-2
URL: http://europepmc.org/abstract/med/25398351
Notch signaling assays in Drosophila cultured cell lines.
Published: 30/11/2013PMID: 25053486
DOI: 10.1007/978-1-4939-1139-4_10
URL: http://europepmc.org/abstract/med/25053486
Visualizing Notch signaling in vivo in Drosophila tissues.
Published: 30/11/2013PMID: 25053484
DOI: 10.1007/978-1-4939-1139-4_8
URL: http://europepmc.org/abstract/med/25053484
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9.
Published: 31/10/2013PMID: 24191015
PMC: PMC3839733
DOI: 10.1073/pnas.1318481110
URL: http://europepmc.org/abstract/med/24191015
2012
Deadpan contributes to the robustness of the notch response.
Published: 30/11/2012PMID: 24086596
PMC: PMC3782438
DOI: 10.1371/journal.pone.0075632
URL: http://europepmc.org/abstract/med/24086596
Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes.
Published: 30/11/2012PMID: 23300480
PMC: PMC3536677
DOI: 10.1371/journal.pgen.1003162
URL: http://europepmc.org/abstract/med/23300480
2011
Drosophila Reporter Vectors Compatible with ΦC31 Integrase Transgenesis Techniques and Their Use to Generate New Notch Reporter Fly Lines.
Published: 31/12/2011PMID: 22384384
PMC: PMC3276196
DOI: 10.1534/g3.111.001321
URL: http://europepmc.org/abstract/med/22384384
2010
Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors.
Published: 31/07/2010PMID: 20610485
PMC: PMC2910383
DOI: 10.1242/dev.053181
URL: http://europepmc.org/abstract/med/20610485
The cytolinker Pigs is a direct target and a negative regulator of Notch signalling.
Published: 28/02/2010PMID: 20150280
PMC: PMC2834460
DOI: 10.1242/dev.043224
URL: http://europepmc.org/abstract/med/20150280
2008
Direct response to Notch activation: signaling crosstalk and incoherent logic.
Published: 31/12/2008PMID: 19176515
DOI: 10.1126/scisignal.2000140
URL: http://europepmc.org/abstract/med/19176515