Dr Jonathan Phillips Senior Lecturer jj.phillips@exeter.ac.uk Living Systems Institute/ Systems Block Groups: Phillips Group University profile 0000-0002-5361-9582 Publications Publications 2024 Improved Detection of Tryptic Peptides from Tissue Sections Using Desorption Electrospray Ionization Mass Spectrometry Imaging Journal: Journal of the American Society for Mass Spectrometry Published: 01/05/2024 DOI: 10.1021/jasms.4c00006 URL: https://doi.org/10.1021/jasms.4c00006 Transient Structural Dynamics of Glycogen Phosphorylase from Nonequilibrium Hydrogen/Deuterium-Exchange Mass Spectrometry Journal: Journal of the American Chemical Society Published: 10/01/2024 DOI: 10.1021/jacs.3c08934 URL: https://doi.org/10.1021/jacs.3c08934 2023 Allosteric activation and inhibition of glycogen phosphorylase share common transient structural features Published: 06/06/2023 DOI: 10.1101/2023.06.03.543583 URL: https://doi.org/10.1101/2023.06.03.543583 Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops Journal: Biochemistry Published: 18/04/2023 DOI: 10.1021/acs.biochem.2c00671 URL: https://doi.org/10.1021/acs.biochem.2c00671 Online Fully Automated System for Hydrogen/Deuterium-Exchange Mass Spectrometry with Millisecond Time Resolution Journal: Analytical Chemistry Published: 21/03/2023 DOI: 10.1021/acs.analchem.2c05310 URL: https://doi.org/10.1021/acs.analchem.2c05310 2022 Mechanistic insights into the rational design of masked antibodies Journal: mAbs Published: 31/12/2022 DOI: 10.1080/19420862.2022.2095701 URL: https://doi.org/10.1080/19420862.2022.2095701 Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein Journal: Analytical Chemistry Published: 06/12/2022 DOI: 10.1021/acs.analchem.2c03183 URL: https://doi.org/10.1021/acs.analchem.2c03183 Engineering and exploiting synthetic allostery of NanoLuc luciferase Journal: Nature Communications Published: 30/11/2022 DOI: 10.1038/s41467-022-28425-2 ISSN: 2041-1723 URL: http://dx.doi.org/10.1038/s41467-022-28425-2 Local structural dynamics of alpha-synuclein correlate with aggregation in different physiological conditions Published: 11/02/2022 DOI: 10.1101/2022.02.11.480045 URL: https://doi.org/10.1101/2022.02.11.480045 2021 HDfleX: Software for Flexible High Structural Resolution of Hydrogen/Deuterium-Exchange Mass Spectrometry Data Published: 10/12/2021 DOI: 10.1101/2021.12.09.471740 URL: https://doi.org/10.1101/2021.12.09.471740 Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation Journal: Bioconjugate Chemistry Published: 18/08/2021 DOI: 10.1021/acs.bioconjchem.1c00286 URL: https://doi.org/10.1021/acs.bioconjchem.1c00286 Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements: Results from an Interlaboratory Comparison Journal: Analytical Chemistry Published: 06/07/2021 DOI: 10.1021/acs.analchem.0c04625 ISSN: 0003-2700 ISSN: 1520-6882 URL: http://dx.doi.org/10.1021/acs.analchem.0c04625 2020 Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity. Journal: Nature communications Published: 31/05/2020 PMID: 32499486 PMC: PMC7272411 DOI: 10.1038/s41467-020-16564-3 URL: http://europepmc.org/abstract/med/32499486 2018 Allosteric regulation of glycogen phosphorylase solution phase structural dynamics at high spatial resolution Journal: bioRxiv Published: 30/11/2018 DOI: 10.1101/654665 EID: 2-s2.0-85095629615 ISSN: 26928205 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85095629615&partnerID=MN8TOARS Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing Journal: Analytical Chemistry Published: 05/06/2018 DOI: 10.1021/acs.analchem.8b01264 URL: https://doi.org/10.1021/acs.analchem.8b01264 C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction Journal: Nature Communications Published: 31/01/2018 DOI: 10.1038/s41467-018-03111-4 ISSN: 2041-1723 URL: 2017 Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues Journal: Analytical Chemistry Published: 21/02/2017 DOI: 10.1021/acs.analchem.6b04158 URL: https://doi.org/10.1021/acs.analchem.6b04158 2016 Ising Model Reprogramming of a Repeat Protein’s Equilibrium Unfolding Pathway Journal: Journal of Molecular Biology Published: 30/04/2016 DOI: 10.1016/j.jmb.2016.02.022 ISSN: 0022-2836 URL: 2015 Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability Journal: Angewandte Chemie International Edition Published: 07/12/2015 DOI: 10.1002/anie.201507223 ISSN: 1433-7851 URL: http://dx.doi.org/10.1002/anie.201507223 Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo Journal: Scientific Reports Published: 30/11/2015 DOI: 10.1038/srep38644 ISSN: 2045-2322 URL: Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase Journal: Nature Communications Published: 23/07/2015 DOI: 10.1038/ncomms8877 URL: https://doi.org/10.1038/ncomms8877 2014 Characterization of Monoclonal Antibody Aggregates and Emerging Technologies Journal: State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 3. Defining the Next Generation of Analytical and Biophysical Techniques Published: 31/12/2014 DOI: 10.1021/bk-2015-1202.ch005 ISBN: 0841230315 ISSN: 0097-6156 URL: Understanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4. Published: 31/01/2014 DOI: 10.1002/jps.23822 PMID: 24357426 URL: http://europepmc.org/abstract/med/24357426 2013 Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks. Published: 30/09/2013 DOI: 10.1042/BST20130102 PMID: 24059501 URL: http://europepmc.org/abstract/med/24059501 2012 Fibrous Nanostructures from the Self-Assembly of Designed Repeat Protein Modules Journal: Angewandte Chemie International Edition Published: 21/12/2012 DOI: 10.1002/anie.201203795 ISSN: 1433-7851 URL: http://dx.doi.org/10.1002/anie.201203795 Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors. Published: 29/02/2012 DOI: 10.1002/pro.2018 PMID: 22170589 PMC: PMC3375434 URL: http://europepmc.org/abstract/med/22170589 2007 Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs. Published: 30/09/2007 DOI: 10.1016/j.jmb.2007.04.059 PMID: 17764690 URL: http://europepmc.org/abstract/med/17764690