Dr Nicola Reynolds Senior Research Fellow N.Reynolds@exeter.ac.uk LSI Groups: Hendrich Group University profile 0000-0003-1620-2750 Publications Publications 2025 The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements Published: 29/08/2025 DOI: 10.1101/2025.08.29.672645 URL: https://doi.org/10.1101/2025.08.29.672645 2024 Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency. Journal: Molecular cell Published: 29/02/2024 PMID: 38490199 PMC: PMC7616059 DOI: 10.1016/j.molcel.2024.02.015 URL: http://europepmc.org/abstract/med/38490199 2023 Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD. Journal: Nature structural & molecular biology Published: 31/08/2023 PMID: 37770717 PMC: PMC10643137 DOI: 10.1038/s41594-023-01095-4 URL: http://europepmc.org/abstract/med/37770717 The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells Published: 10/02/2023 DOI: 10.1101/2023.02.09.527610 URL: https://doi.org/10.1101/2023.02.09.527610 Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency Published: 08/02/2023 DOI: 10.1101/2023.02.08.527615 URL: https://doi.org/10.1101/2023.02.08.527615 2020 Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by the nucleosome remodelling and deacetylation complex. Journal: Elsevier BV Published: 05/06/2020 DOI: 10.17863/cam.53249 URL: Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics Published: 31/03/2020 OTHER-ID: PPR139209 DOI: 10.1101/2020.04.03.003178 URL: http://europepmc.org/abstract/PPR/PPR139209 2019 The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment. Journal: Springer Science and Business Media LLC Published: 12/04/2019 DOI: 10.17863/cam.38722 URL: 2018 The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression. Journal: Molecular cell Published: 31/05/2018 PMID: 30008319 PMC: PMC6039721 DOI: 10.1016/j.molcel.2018.06.003 URL: http://europepmc.org/abstract/med/30008319