Prof Steffen Scholpp Professor of Cell & Developmental Biology S.Scholpp@exeter.ac.uk CLES Groups: Scholpp Group University profile 0000-0002-4903-9657 Publications Publications 2024 Cytoneme-mediated transport of active Wnt5b–Ror2 complexes in zebrafish Journal: Nature Published: 04/01/2024 DOI: 10.1038/s41586-023-06850-7 URL: https://doi.org/10.1038/s41586-023-06850-7 2023 Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2 Journal: Proceedings of the National Academy of Sciences Published: 26/09/2023 DOI: 10.1073/pnas.2217612120 URL: https://doi.org/10.1073/pnas.2217612120 Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons. Published: 17/02/2023 DOI: 10.1101/2023.02.17.528927 URL: https://doi.org/10.1101/2023.02.17.528927 2022 The scaffolding protein Flot2 promotes cytoneme-based transport of Wnt3 in gastric cancer Journal: eLife Published: 30/08/2022 DOI: 10.7554/eLife.77376 URL: https://doi.org/10.7554/eLife.77376 Vertebrate Wnt5a – At the crossroads of cellular signalling Journal: Seminars in Cell & Developmental Biology Published: 30/04/2022 DOI: 10.1016/j.semcdb.2021.10.002 URL: https://doi.org/10.1016/j.semcdb.2021.10.002 Cancer-associated fibroblast-derived ROR2 induces WNT/PCP activation and polarized migration in receiving gastric cancer cells Published: 08/04/2022 DOI: 10.1101/2022.04.07.487474 URL: https://doi.org/10.1101/2022.04.07.487474 Cytoneme-mediated transport of active Wnt5b/Ror2 complexes in zebrafish gastrulation Published: 08/04/2022 DOI: 10.1101/2022.04.07.487468 URL: https://doi.org/10.1101/2022.04.07.487468 The scaffolding protein Flot2 regulates cytoneme-based transport of Wnt3 in gastric cancer Published: 08/01/2022 DOI: 10.1101/2022.01.07.475396 URL: https://doi.org/10.1101/2022.01.07.475396 2021 A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery Published: 14/09/2021 DOI: 10.1101/2021.09.14.460241 URL: https://doi.org/10.1101/2021.09.14.460241 Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling Journal: Nature Communications Published: 06/04/2021 DOI: 10.1038/s41467-021-22393-9 URL: https://doi.org/10.1038/s41467-021-22393-9 2020 Vangl2 regulates the dynamics of Wnt cytonemes in vertebrates Published: 23/12/2020 DOI: 10.1101/2020.12.23.424142 URL: https://doi.org/10.1101/2020.12.23.424142 Delay-driven oscillations via Axin2 feedback in the Wnt/β-catenin signalling pathway Journal: Journal of Theoretical Biology Published: 30/11/2020 DOI: 10.1016/j.jtbi.2020.110458 URL: https://doi.org/10.1016/j.jtbi.2020.110458 Introduction: in vivo cell biology in zebrafish. Journal: Histochemistry and cell biology Published: 29/10/2020 PMID: 33118079 DOI: 10.1007/s00418-020-01931-4 URL: https://doi.org/10.1007/s00418-020-01931-4 Studying molecular interactions in the intact organism: fluorescence correlation spectroscopy in the living zebrafish embryo. Journal: Histochemistry and cell biology Published: 16/10/2020 PMID: 33067656 PMC: PMC7609432 DOI: 10.1007/s00418-020-01930-5 URL: https://europepmc.org/articles/PMC7609432 Development of the electric organ in embryos and larvae of the knifefish, Brachyhypopomus gauderio Journal: Developmental Biology Published: 30/09/2020 DOI: 10.1016/j.ydbio.2020.06.010 URL: https://doi.org/10.1016/j.ydbio.2020.06.010 Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis Journal: PLOS Computational Biology Published: 24/06/2020 DOI: 10.1371/journal.pcbi.1007417 URL: https://doi.org/10.1371/journal.pcbi.1007417 2019 Cytonemes in development Journal: Current Opinion in Genetics & Development Published: 31/07/2019 DOI: 10.1016/j.gde.2019.06.005 ISSN: 0959-437X URL: http://dx.doi.org/10.1016/j.gde.2019.06.005 Mechanisms of intercellular Wnt transport Journal: Development Published: 15/05/2019 DOI: 10.1242/dev.176073 URL: https://doi.org/10.1242/dev.176073 2018 From top to bottom: Cell polarity in Hedgehog and Wnt trafficking Journal: BMC Biology Published: 30/11/2018 DOI: 10.1186/s12915-018-0511-x URL: https://doi.org/10.1186/s12915-018-0511-x Emerging role of contact-mediated cell communication in tissue development and diseases Journal: Histochemistry and Cell Biology Published: 25/11/2018 DOI: 10.1007/s00418-018-1732-3 URL: https://doi.org/10.1007/s00418-018-1732-3 Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. Journal: eLife Published: 30/06/2018 PMID: 30060804 DOI: 10.7554/elife.36953 URL: http://europepmc.org/abstract/med/30060804 Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Journal: Science (New York, N.Y.) Published: 31/03/2018 PMID: 29674564 DOI: 10.1126/science.aaq1392 URL: http://europepmc.org/abstract/med/29674564 The function of endocytosis in Wnt signaling. Journal: Cellular and molecular life sciences : CMLS Published: 28/02/2018 PMID: 28913633 PMC: PMC5809524 DOI: 10.1007/s00018-017-2654-2 URL: http://europepmc.org/abstract/med/28913633 2016 Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. Published: 31/03/2016 PMID: 27129770 URL: http://europepmc.org/abstract/med/27129770 2015 Role of cytonemes in Wnt transport. Published: 31/12/2015 PMID: 26823607 URL: http://europepmc.org/abstract/med/26823607 Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Published: 31/03/2015 PMID: 25787094 DOI: 10.1002/adma.201500426 URL: http://europepmc.org/abstract/med/25787094 2014 Filopodia-based Wnt transport during vertebrate tissue patterning. Published: 30/11/2014 PMID: 25556612 DOI: 10.1038/ncomms6846 URL: http://europepmc.org/abstract/med/25556612 Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling. Published: 30/11/2014 PMID: 25391905 DOI: 10.15252/embr.201439644 URL: http://europepmc.org/abstract/med/25391905 2013 Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. Published: 30/11/2013 PMID: 24466061 PMC: PMC3896487 DOI: 10.1371/journal.pone.0086373 URL: http://europepmc.org/abstract/med/24466061 In vivo analysis of formation and endocytosis of the Wnt/beta-Catenin signaling complex in zebrafish embryos. Journal: Journal of cell science Published: 30/11/2013 DOI: 10.1242/jcs.148767 URL: Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates Published: 30/11/2013 DOI: 10.1186/1741-7007-12-13 EID: 2-s2.0-84899141018 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899141018&partnerID=MN8TOARS 2012 Brain on the stage – Spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013 Published: 30/11/2012 DOI: 10.1186/1749-8104-8-23 EID: 2-s2.0-84890403284 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84890403284&partnerID=MN8TOARS Building the gateway to consciousness-about the development of the thalamus. Published: 30/11/2012 PMID: 23760777 PMC: PMC3671175 DOI: 10.3389/fnins.2013.00094 URL: http://europepmc.org/abstract/med/23760777 Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell-cell communication Published: 30/11/2012 DOI: 10.1016/j.biomaterials.2012.11.034 EID: 2-s2.0-84871095068 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871095068&partnerID=MN8TOARS Neurogenesis in zebrafish – from embryo to adult Published: 30/11/2012 DOI: 10.1186/1749-8104-8-3 EID: 2-s2.0-84874007223 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874007223&partnerID=MN8TOARS 2011 The tale of the three brothers – Shh, Wnt, and Fgf during development of the thalamus Published: 30/11/2011 DOI: 10.3389/fnins.2012.00076 EID: 2-s2.0-84862228793 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862228793&partnerID=MN8TOARS Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain Published: 30/11/2011 DOI: 10.1186/1749-8104-7-12 EID: 2-s2.0-84859189794 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84859189794&partnerID=MN8TOARS 2010 Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling Published: 30/11/2010 DOI: 10.1371/journal.pbio.1001218 EID: 2-s2.0-84855176609 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855176609&partnerID=MN8TOARS 2009 Building a bridal chamber: Development of the thalamus Published: 30/11/2009 DOI: 10.1016/j.tins.2010.05.003 EID: 2-s2.0-77955279065 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77955279065&partnerID=MN8TOARS Molecular pathways controlling development of thalamus and hypothalamus: From neural specification to circuit formation Published: 30/11/2009 DOI: 10.1523/JNEUROSCI.4499-10.2010 EID: 2-s2.0-78149482636 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78149482636&partnerID=MN8TOARS Neural Patterning: Midbrain-Hindbrain Boundary Published: 30/11/2009 DOI: 10.1016/B978-008045046-9.01066-4 EID: 2-s2.0-84882822385 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84882822385&partnerID=MN8TOARS Ontogenesis of the brain: The development of the thalamus – The gateway to consciousness | Ontogenese des Gehirns Die Entwicklung des Thalamus -das Tor zum Bewusstsein Published: 30/11/2009 EID: 2-s2.0-77958039986 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958039986&partnerID=MN8TOARS Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway Published: 30/11/2009 DOI: 10.1038/nn.2662 EID: 2-s2.0-78049287669 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78049287669&partnerID=MN8TOARS 2008 Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules Published: 30/11/2008 DOI: 10.1038/nature08391 EID: 2-s2.0-70349453919 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-70349453919&partnerID=MN8TOARS Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus Published: 30/11/2008 DOI: 10.1073/pnas.0910894106 EID: 2-s2.0-73949152966 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-73949152966&partnerID=MN8TOARS 2006 Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals Published: 30/11/2006 DOI: 10.1242/dev.02872 EID: 2-s2.0-34547483655 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547483655&partnerID=MN8TOARS Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon Published: 30/11/2006 DOI: 10.1242/dev.001461 EID: 2-s2.0-34848847165 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34848847165&partnerID=MN8TOARS Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries Published: 30/11/2006 DOI: 10.1016/j.ydbio.2006.08.022 EID: 2-s2.0-33846258014 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846258014&partnerID=MN8TOARS 2005 Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon Published: 30/11/2005 DOI: 10.1242/dev.02248 EID: 2-s2.0-32344446690 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-32344446690&partnerID=MN8TOARS 2003 Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Published: 30/11/2003 EID: 2-s2.0-3543006549 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3543006549&partnerID=MN8TOARS Endocytosis controls spreading and effective signaling range of Fgf8 protein Published: 30/11/2003 DOI: 10.1016/j.cub.2004.09.084 EID: 2-s2.0-6944255474 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-6944255474&partnerID=MN8TOARS Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary Published: 30/11/2003 EID: 2-s2.0-3543006549 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3543006549&partnerID=MN8TOARS 2002 Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon Published: 30/11/2002 DOI: 10.1242/dev.00683 EID: 2-s2.0-0142181010 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0142181010&partnerID=MN8TOARS Erratum: Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (Development vol. 130 (4881-4893)) Published: 30/11/2002 EID: 2-s2.0-0242719723 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0242719723&partnerID=MN8TOARS Integrity of the Midbrain Region Is Required to Maintain the Diencephalic-Mesencephalic Boundary in Zebrafish no isthmus/pax2.1 Mutants Published: 30/11/2002 DOI: 10.1002/dvdy.10384 EID: 2-s2.0-0142222325 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0142222325&partnerID=MN8TOARS 2001 A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Published: 30/11/2001 EID: 2-s2.0-0036333606 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036333606&partnerID=MN8TOARS A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines Published: 30/11/2001 EID: 2-s2.0-0036333606 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036333606&partnerID=MN8TOARS 2000 Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain-hindbrain boundary development Published: 30/11/2000 DOI: 10.1002/gene.1047 EID: 2-s2.0-0034908357 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034908357&partnerID=MN8TOARS