Prof Steffen Scholpp

Professor of Cell & Developmental Biology

S.Scholpp@exeter.ac.uk

CLES

Groups: Scholpp Group

University profile

0000-0002-4903-9657

Publications

2023

Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2

Journal: Proceedings of the National Academy of Sciences

Published: 26/09/2023
DOI: 10.1073/pnas.2217612120
URL: https://doi.org/10.1073/pnas.2217612120

Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons.

Published: 17/02/2023
DOI: 10.1101/2023.02.17.528927
URL: https://doi.org/10.1101/2023.02.17.528927

2022

The scaffolding protein Flot2 promotes cytoneme-based transport of Wnt3 in gastric cancer

Journal: eLife

Published: 30/08/2022
DOI: 10.7554/eLife.77376
URL: https://doi.org/10.7554/eLife.77376

Vertebrate Wnt5a – At the crossroads of cellular signalling

Journal: Seminars in Cell & Developmental Biology

Published: 30/04/2022
DOI: 10.1016/j.semcdb.2021.10.002
URL: https://doi.org/10.1016/j.semcdb.2021.10.002

Cancer-associated fibroblast-derived ROR2 induces WNT/PCP activation and polarized migration in receiving gastric cancer cells

Published: 08/04/2022
DOI: 10.1101/2022.04.07.487474
URL: https://doi.org/10.1101/2022.04.07.487474

Cytoneme-mediated transport of active Wnt5b/Ror2 complexes in zebrafish gastrulation

Published: 08/04/2022
DOI: 10.1101/2022.04.07.487468
URL: https://doi.org/10.1101/2022.04.07.487468

The scaffolding protein Flot2 regulates cytoneme-based transport of Wnt3 in gastric cancer

Published: 08/01/2022
DOI: 10.1101/2022.01.07.475396
URL: https://doi.org/10.1101/2022.01.07.475396

2021

A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery

Published: 14/09/2021
DOI: 10.1101/2021.09.14.460241
URL: https://doi.org/10.1101/2021.09.14.460241

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

Journal: Nature Communications

Published: 06/04/2021
DOI: 10.1038/s41467-021-22393-9
URL: https://doi.org/10.1038/s41467-021-22393-9

2020

Vangl2 regulates the dynamics of Wnt cytonemes in vertebrates

Published: 23/12/2020
DOI: 10.1101/2020.12.23.424142
URL: https://doi.org/10.1101/2020.12.23.424142

Delay-driven oscillations via Axin2 feedback in the Wnt/β-catenin signalling pathway

Journal: Journal of Theoretical Biology

Published: 30/11/2020
DOI: 10.1016/j.jtbi.2020.110458
URL: https://doi.org/10.1016/j.jtbi.2020.110458

Introduction: in vivo cell biology in zebrafish.

Journal: Histochemistry and cell biology

Published: 29/10/2020
PMID: 33118079
DOI: 10.1007/s00418-020-01931-4
URL: https://doi.org/10.1007/s00418-020-01931-4

Studying molecular interactions in the intact organism: fluorescence correlation spectroscopy in the living zebrafish embryo.

Journal: Histochemistry and cell biology

Published: 16/10/2020
PMID: 33067656
PMC: PMC7609432
DOI: 10.1007/s00418-020-01930-5
URL: https://europepmc.org/articles/PMC7609432

Development of the electric organ in embryos and larvae of the knifefish, Brachyhypopomus gauderio

Journal: Developmental Biology

Published: 30/09/2020
DOI: 10.1016/j.ydbio.2020.06.010
URL: https://doi.org/10.1016/j.ydbio.2020.06.010

Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis

Journal: PLOS Computational Biology

Published: 24/06/2020
DOI: 10.1371/journal.pcbi.1007417
URL: https://doi.org/10.1371/journal.pcbi.1007417

2019

Cytonemes in development

Journal: Current Opinion in Genetics & Development

Published: 31/07/2019
DOI: 10.1016/j.gde.2019.06.005
ISSN: 0959-437X
URL: http://dx.doi.org/10.1016/j.gde.2019.06.005

Mechanisms of intercellular Wnt transport

Journal: Development

Published: 15/05/2019
DOI: 10.1242/dev.176073
URL: https://doi.org/10.1242/dev.176073

2018

From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

Journal: BMC Biology

Published: 30/11/2018
DOI: 10.1186/s12915-018-0511-x
URL: https://doi.org/10.1186/s12915-018-0511-x

Emerging role of contact-mediated cell communication in tissue development and diseases

Journal: Histochemistry and Cell Biology

Published: 25/11/2018
DOI: 10.1007/s00418-018-1732-3
URL: https://doi.org/10.1007/s00418-018-1732-3

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates.

Journal: eLife

Published: 30/06/2018
PMID: 30060804
DOI: 10.7554/elife.36953
URL: http://europepmc.org/abstract/med/30060804

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Journal: Science (New York, N.Y.)

Published: 31/03/2018
PMID: 29674564
DOI: 10.1126/science.aaq1392
URL: http://europepmc.org/abstract/med/29674564

The function of endocytosis in Wnt signaling.

Journal: Cellular and molecular life sciences : CMLS

Published: 28/02/2018
PMID: 28913633
PMC: PMC5809524
DOI: 10.1007/s00018-017-2654-2
URL: http://europepmc.org/abstract/med/28913633

2016

Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation.

Published: 31/03/2016
PMID: 27129770
URL: http://europepmc.org/abstract/med/27129770

2015

Role of cytonemes in Wnt transport.

Published: 31/12/2015
PMID: 26823607
URL: http://europepmc.org/abstract/med/26823607

Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding.

Published: 31/03/2015
PMID: 25787094
DOI: 10.1002/adma.201500426
URL: http://europepmc.org/abstract/med/25787094

2014

Filopodia-based Wnt transport during vertebrate tissue patterning.

Published: 30/11/2014
PMID: 25556612
DOI: 10.1038/ncomms6846
URL: http://europepmc.org/abstract/med/25556612

Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling.

Published: 30/11/2014
PMID: 25391905
DOI: 10.15252/embr.201439644
URL: http://europepmc.org/abstract/med/25391905

2013

Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling.

Published: 30/11/2013
PMID: 24466061
PMC: PMC3896487
DOI: 10.1371/journal.pone.0086373
URL: http://europepmc.org/abstract/med/24466061

In vivo analysis of formation and endocytosis of the Wnt/beta-Catenin signaling complex in zebrafish embryos.

Journal: Journal of cell science

Published: 30/11/2013
DOI: 10.1242/jcs.148767
URL:

Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates

Published: 30/11/2013
DOI: 10.1186/1741-7007-12-13
EID: 2-s2.0-84899141018
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899141018&partnerID=MN8TOARS

2012

Brain on the stage – Spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013

Published: 30/11/2012
DOI: 10.1186/1749-8104-8-23
EID: 2-s2.0-84890403284
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84890403284&partnerID=MN8TOARS

Building the gateway to consciousness-about the development of the thalamus.

Published: 30/11/2012
PMID: 23760777
PMC: PMC3671175
DOI: 10.3389/fnins.2013.00094
URL: http://europepmc.org/abstract/med/23760777

Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell-cell communication

Published: 30/11/2012
DOI: 10.1016/j.biomaterials.2012.11.034
EID: 2-s2.0-84871095068
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871095068&partnerID=MN8TOARS

Neurogenesis in zebrafish – from embryo to adult

Published: 30/11/2012
DOI: 10.1186/1749-8104-8-3
EID: 2-s2.0-84874007223
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874007223&partnerID=MN8TOARS

2011

The tale of the three brothers – Shh, Wnt, and Fgf during development of the thalamus

Published: 30/11/2011
DOI: 10.3389/fnins.2012.00076
EID: 2-s2.0-84862228793
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862228793&partnerID=MN8TOARS

Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain

Published: 30/11/2011
DOI: 10.1186/1749-8104-7-12
EID: 2-s2.0-84859189794
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84859189794&partnerID=MN8TOARS

2010

Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling

Published: 30/11/2010
DOI: 10.1371/journal.pbio.1001218
EID: 2-s2.0-84855176609
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855176609&partnerID=MN8TOARS

2009

Building a bridal chamber: Development of the thalamus

Published: 30/11/2009
DOI: 10.1016/j.tins.2010.05.003
EID: 2-s2.0-77955279065
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77955279065&partnerID=MN8TOARS

Molecular pathways controlling development of thalamus and hypothalamus: From neural specification to circuit formation

Published: 30/11/2009
DOI: 10.1523/JNEUROSCI.4499-10.2010
EID: 2-s2.0-78149482636
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78149482636&partnerID=MN8TOARS

Neural Patterning: Midbrain-Hindbrain Boundary

Published: 30/11/2009
DOI: 10.1016/B978-008045046-9.01066-4
EID: 2-s2.0-84882822385
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84882822385&partnerID=MN8TOARS

Ontogenesis of the brain: The development of the thalamus – The gateway to consciousness | Ontogenese des Gehirns Die Entwicklung des Thalamus -das Tor zum Bewusstsein

Published: 30/11/2009
EID: 2-s2.0-77958039986
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958039986&partnerID=MN8TOARS

Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway

Published: 30/11/2009
DOI: 10.1038/nn.2662
EID: 2-s2.0-78049287669
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78049287669&partnerID=MN8TOARS

2008

Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules

Published: 30/11/2008
DOI: 10.1038/nature08391
EID: 2-s2.0-70349453919
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-70349453919&partnerID=MN8TOARS

Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus

Published: 30/11/2008
DOI: 10.1073/pnas.0910894106
EID: 2-s2.0-73949152966
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-73949152966&partnerID=MN8TOARS

2006

Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals

Published: 30/11/2006
DOI: 10.1242/dev.02872
EID: 2-s2.0-34547483655
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547483655&partnerID=MN8TOARS

Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon

Published: 30/11/2006
DOI: 10.1242/dev.001461
EID: 2-s2.0-34848847165
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34848847165&partnerID=MN8TOARS

Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries

Published: 30/11/2006
DOI: 10.1016/j.ydbio.2006.08.022
EID: 2-s2.0-33846258014
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846258014&partnerID=MN8TOARS

2005

Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon

Published: 30/11/2005
DOI: 10.1242/dev.02248
EID: 2-s2.0-32344446690
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-32344446690&partnerID=MN8TOARS

2003

Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary.

Published: 30/11/2003
EID: 2-s2.0-3543006549
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3543006549&partnerID=MN8TOARS

Endocytosis controls spreading and effective signaling range of Fgf8 protein

Published: 30/11/2003
DOI: 10.1016/j.cub.2004.09.084
EID: 2-s2.0-6944255474
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-6944255474&partnerID=MN8TOARS

Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary

Published: 30/11/2003
EID: 2-s2.0-3543006549
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3543006549&partnerID=MN8TOARS

2002

Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon

Published: 30/11/2002
DOI: 10.1242/dev.00683
EID: 2-s2.0-0142181010
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0142181010&partnerID=MN8TOARS

Erratum: Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (Development vol. 130 (4881-4893))

Published: 30/11/2002
EID: 2-s2.0-0242719723
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0242719723&partnerID=MN8TOARS

Integrity of the Midbrain Region Is Required to Maintain the Diencephalic-Mesencephalic Boundary in Zebrafish no isthmus/pax2.1 Mutants

Published: 30/11/2002
DOI: 10.1002/dvdy.10384
EID: 2-s2.0-0142222325
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0142222325&partnerID=MN8TOARS

2001

A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines.

Published: 30/11/2001
EID: 2-s2.0-0036333606
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036333606&partnerID=MN8TOARS

A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines

Published: 30/11/2001
EID: 2-s2.0-0036333606
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036333606&partnerID=MN8TOARS

2000

Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain-hindbrain boundary development

Published: 30/11/2000
DOI: 10.1002/gene.1047
EID: 2-s2.0-0034908357
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034908357&partnerID=MN8TOARS