Prof Steffen Scholpp Professor of Cell & Developmental Biology S.Scholpp@exeter.ac.uk CLES Groups: Scholpp Group University profile 0000-0002-4903-9657 Publications Publications 2025 Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer’s disease Journal: Journal of Cell Science Published: 01/02/2025 DOI: 10.1242/jcs.263526 URL: https://doi.org/10.1242/jcs.263526 2024 Innate versus adoptive competence: the controlled distribution of signalling receptors extends the concept of competence Journal: Trends in Cell Biology Published: 31/12/2024 DOI: 10.1016/j.tcb.2024.12.005 URL: https://doi.org/10.1016/j.tcb.2024.12.005 Wnt7a-positive dendritic cytonemes control synaptogenesis in cortical neurons Journal: Development Published: 01/12/2024 DOI: 10.1242/dev.202868 URL: https://doi.org/10.1242/dev.202868 Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer’s disease. Published: 17/07/2024 DOI: 10.1101/2024.07.16.603668 URL: https://doi.org/10.1101/2024.07.16.603668 Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer’s disease Published: 17/07/2024 DOI: 10.1101/2024.07.16.603668 URL: https://doi.org/10.1101/2024.07.16.603668 2023 Cytoneme-mediated transport of active Wnt5b–Ror2 complexes in zebrafish Journal: Nature Published: 30/11/2023 DOI: 10.1038/s41586-023-06850-7 EID: 2-s2.0-85180256334 ISSN: 14764687 00280836 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85180256334&partnerID=MN8TOARS Transport and gradient formation of Wnt and Fgf in the early zebrafish gastrula Journal: Current Topics in Developmental Biology Published: 30/11/2023 DOI: 10.1016/bs.ctdb.2023.12.003 EID: 2-s2.0-85181235256 ISBN: 9780128237595 ISSN: 00702153 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85181235256&partnerID=MN8TOARS Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2 Journal: Proceedings of the National Academy of Sciences Published: 26/09/2023 DOI: 10.1073/pnas.2217612120 URL: https://doi.org/10.1073/pnas.2217612120 2022 The scaffolding protein Flot2 promotes cytoneme-based transport of Wnt3 in gastric cancer Journal: eLife Published: 30/08/2022 DOI: 10.7554/elife.77376 ISSN: 2050-084X URL: http://dx.doi.org/10.7554/elife.77376 Cancer-associated fibroblast-derived ROR2 induces WNT/PCP activation and polarized migration in receiving gastric cancer cells Published: 08/04/2022 DOI: 10.1101/2022.04.07.487474 URL: https://doi.org/10.1101/2022.04.07.487474 Cytoneme-mediated transport of active Wnt5b/Ror2 complexes in zebrafish gastrulation Published: 08/04/2022 DOI: 10.1101/2022.04.07.487468 URL: https://doi.org/10.1101/2022.04.07.487468 The scaffolding protein Flot2 regulates cytoneme-based transport of Wnt3 in gastric cancer Published: 08/01/2022 DOI: 10.1101/2022.01.07.475396 URL: https://doi.org/10.1101/2022.01.07.475396 2021 A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation Journal: Frontiers in Pharmacology Published: 30/11/2021 DOI: 10.3389/fphar.2022.827686 EID: 2-s2.0-85129847989 ISSN: 16639812 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85129847989&partnerID=MN8TOARS Vertebrate Wnt5a – At the crossroads of cellular signalling Journal: Seminars in Cell and Developmental Biology Published: 30/11/2021 DOI: 10.1016/j.semcdb.2021.10.002 EID: 2-s2.0-85118618343 ISSN: 10963634 10849521 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85118618343&partnerID=MN8TOARS Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling Journal: Nature Communications Published: 30/11/2021 DOI: 10.1038/s41467-021-22393-9 ISSN: 2041-1723 URL: http://dx.doi.org/10.1038/s41467-021-22393-9 The scaffolding protein flot2 promotecytoneme-based transport of wnt3 in gastric cancer Journal: eLife Published: 30/11/2021 DOI: 10.7554/eLife.77376 EID: 2-s2.0-85138125432 ISSN: 2050084X URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85138125432&partnerID=MN8TOARS A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery Published: 14/09/2021 DOI: 10.1101/2021.09.14.460241 URL: https://doi.org/10.1101/2021.09.14.460241 2020 Vangl2 regulates the dynamics of Wnt cytonemes in vertebrates Published: 23/12/2020 DOI: 10.1101/2020.12.23.424142 URL: https://doi.org/10.1101/2020.12.23.424142 Review: The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish Journal: Frontiers in Cell and Developmental Biology Published: 30/11/2020 DOI: 10.3389/fcell.2021.782445 ISSN: 2296-634X URL: https://www.frontiersin.org/article/10.3389/fcell.2021.782445 Preserving Cytonemes for Immunocytochemistry of Cultured Adherent Cells Journal: Methods in Molecular Biology Published: 30/11/2020 DOI: 10.1007/7651_2020_305 EID: 2-s2.0-85106061587 ISSN: 19406029 10643745 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85106061587&partnerID=MN8TOARS Introduction: in vivo cell biology in zebrafish. Journal: Histochemistry and cell biology Published: 29/10/2020 PMID: 33118079 DOI: 10.1007/s00418-020-01931-4 URL: https://doi.org/10.1007/s00418-020-01931-4 Studying molecular interactions in the intact organism: fluorescence correlation spectroscopy in the living zebrafish embryo. Journal: Histochemistry and cell biology Published: 16/10/2020 PMID: 33067656 PMC: PMC7609432 DOI: 10.1007/s00418-020-01930-5 URL: https://europepmc.org/articles/PMC7609432 Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis Journal: PLOS Computational Biology Published: 24/06/2020 DOI: 10.1371/journal.pcbi.1007417 ISSN: 1553-7358 URL: http://dx.doi.org/10.1371/journal.pcbi.1007417 2019 Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish Journal: Histochemistry and Cell Biology Published: 30/11/2019 DOI: 10.1007/s00418-020-01887-5 EID: 2-s2.0-85085883116 ISSN: 1432119X 09486143 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85085883116&partnerID=MN8TOARS Development of the electric organ in embryos and larvae of the knifefish, Brachyhypopomus gauderio Journal: Developmental Biology Published: 30/11/2019 DOI: 10.1016/j.ydbio.2020.06.010 EID: 2-s2.0-85089253008 ISSN: 1095564X 00121606 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85089253008&partnerID=MN8TOARS Delay-driven oscillations via Axin2 feedback in the Wnt/β-catenin signalling pathway Journal: Journal of Theoretical Biology Published: 30/11/2019 DOI: 10.1016/j.jtbi.2020.110458 EID: 2-s2.0-85090296171 ISSN: 10958541 00225193 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85090296171&partnerID=MN8TOARS Cytonemes in development Journal: Current Opinion in Genetics & Development Published: 31/07/2019 DOI: 10.1016/j.gde.2019.06.005 ISSN: 0959-437X URL: http://dx.doi.org/10.1016/j.gde.2019.06.005 2018 Mechanisms of intercellular Wnt transport Journal: Development (Cambridge) Published: 30/11/2018 DOI: 10.1242/dev.176073 EID: 2-s2.0-85066863338 ISSN: 14779129 09501991 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85066863338&partnerID=MN8TOARS From top to bottom: Cell polarity in Hedgehog and Wnt trafficking Journal: BMC Biology Published: 30/11/2018 DOI: 10.1186/s12915-018-0511-x ISSN: 1741-7007 URL: http://dx.doi.org/10.1186/s12915-018-0511-x The function of endocytosis in Wnt signaling. Journal: Cellular and Molecular Life Sciences Published: 28/02/2018 DOI: 10.1007/s00018-017-2654-2 ISSN: 1420-682X ISSN: 1420-9071 URL: http://dx.doi.org/10.1007/s00018-017-2654-2 2017 Emerging role of contact-mediated cell communication in tissue development and diseases Journal: Histochemistry and Cell Biology Published: 30/11/2017 DOI: 10.1007/s00418-018-1732-3 EID: 2-s2.0-85053753734 ISSN: 1432119X 09486143 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85053753734&partnerID=MN8TOARS Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. Journal: eLife Published: 30/11/2017 DOI: 10.7554/eLife.36953 EID: 2-s2.0-85052057330 ISSN: 2050084X URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85052057330&partnerID=MN8TOARS Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Journal: Science Published: 30/11/2017 DOI: 10.1126/science.aaq1392 EID: 2-s2.0-85045622293 ISSN: 10959203 00368075 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85045622293&partnerID=MN8TOARS 2015 Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. Journal: Journal of Biological Chemistry Published: 30/11/2015 DOI: 10.1074/jbc.M116.733766 EID: 2-s2.0-84975886720 ISSN: 1083351X 00219258 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84975886720&partnerID=MN8TOARS Role of cytonemes in Wnt transport. Journal: Journal of Cell Science Published: 30/11/2015 DOI: 10.1242/jcs.182469 EID: 2-s2.0-84961215829 ISSN: 14779137 00219533 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84961215829&partnerID=MN8TOARS 2014 Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Journal: Advanced Materials Published: 30/11/2014 DOI: 10.1002/adma.201500426 EID: 2-s2.0-84928040873 ISSN: 15214095 09359648 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84928040873&partnerID=MN8TOARS Filopodia-based Wnt transport during vertebrate tissue patterning. Journal: Nature Communications Published: 30/11/2014 DOI: 10.1038/ncomms6846 EID: 2-s2.0-84937547475 ISSN: 20411723 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84937547475&partnerID=MN8TOARS 2013 Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling. Journal: EMBO Reports Published: 30/11/2013 DOI: 10.15252/embr.201439644 EID: 2-s2.0-84915827868 ISSN: 14693178 1469221X URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84915827868&partnerID=MN8TOARS Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. Journal: PLoS ONE Published: 30/11/2013 DOI: 10.1371/journal.pone.0086373 EID: 2-s2.0-84925225398 ISSN: 19326203 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84925225398&partnerID=MN8TOARS In vivo analysis of formation and endocytosis of the Wnt/beta-Catenin signaling complex in zebrafish embryos. Journal: Journal of cell science Published: 30/11/2013 DOI: 10.1242/jcs.148767 URL: Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates Published: 30/11/2013 DOI: 10.1186/1741-7007-12-13 EID: 2-s2.0-84899141018 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899141018&partnerID=MN8TOARS Correction to In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos [J. Cell Sci. 127, (2014) 3970-3982] Journal: Journal of Cell Science Published: 30/11/2013 DOI: 10.1242/jcs.165704 EID: 2-s2.0-84918561970 ISSN: 14779137 00219533 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84918561970&partnerID=MN8TOARS In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos Journal: Journal of Cell Science Published: 30/11/2013 DOI: 10.1242/jcs.148767 EID: 2-s2.0-84907042839 ISSN: 14779137 00219533 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84907042839&partnerID=MN8TOARS 2012 Brain on the stage – Spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013 Published: 30/11/2012 DOI: 10.1186/1749-8104-8-23 EID: 2-s2.0-84890403284 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84890403284&partnerID=MN8TOARS Building the gateway to consciousness-about the development of the thalamus. Published: 30/11/2012 PMID: 23760777 PMC: PMC3671175 DOI: 10.3389/fnins.2013.00094 URL: http://europepmc.org/abstract/med/23760777 Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell-cell communication Published: 30/11/2012 DOI: 10.1016/j.biomaterials.2012.11.034 EID: 2-s2.0-84871095068 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871095068&partnerID=MN8TOARS Neurogenesis in zebrafish – from embryo to adult Published: 30/11/2012 DOI: 10.1186/1749-8104-8-3 EID: 2-s2.0-84874007223 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874007223&partnerID=MN8TOARS 2011 The tale of the three brothers – Shh, Wnt, and Fgf during development of the thalamus Published: 30/11/2011 DOI: 10.3389/fnins.2012.00076 EID: 2-s2.0-84862228793 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84862228793&partnerID=MN8TOARS Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain Published: 30/11/2011 DOI: 10.1186/1749-8104-7-12 EID: 2-s2.0-84859189794 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84859189794&partnerID=MN8TOARS 2010 Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling Published: 30/11/2010 DOI: 10.1371/journal.pbio.1001218 EID: 2-s2.0-84855176609 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84855176609&partnerID=MN8TOARS 2009 Building a bridal chamber: Development of the thalamus Published: 30/11/2009 DOI: 10.1016/j.tins.2010.05.003 EID: 2-s2.0-77955279065 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77955279065&partnerID=MN8TOARS Molecular pathways controlling development of thalamus and hypothalamus: From neural specification to circuit formation Journal: Journal of Neuroscience Published: 30/11/2009 DOI: 10.1523/JNEUROSCI.4499-10.2010 EID: 2-s2.0-78149482636 ISSN: 02706474 15292401 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78149482636&partnerID=MN8TOARS Ontogenesis of the brain: The development of the thalamus – The gateway to consciousness | Ontogenese des Gehirns Die Entwicklung des Thalamus -das Tor zum Bewusstsein Published: 30/11/2009 EID: 2-s2.0-77958039986 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958039986&partnerID=MN8TOARS Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway Published: 30/11/2009 DOI: 10.1038/nn.2662 EID: 2-s2.0-78049287669 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-78049287669&partnerID=MN8TOARS Ontogenesis of the brain: The development of the thalamus – The gateway to consciousness,Ontogenese des Gehirns Die Entwicklung des Thalamus -das Tor zum Bewusstsein Journal: BioSpektrum Published: 30/11/2009 EID: 2-s2.0-77958039986 ISSN: 09470867 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958039986&partnerID=MN8TOARS 2008 Neural Patterning: Midbrain-Hindbrain Boundary Journal: Encyclopedia of Neuroscience Published: 30/11/2008 DOI: 10.1016/B978-008045046-9.01066-4 EID: 2-s2.0-84882822385 ISBN: 9780080450469 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-84882822385&partnerID=MN8TOARS Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules Published: 30/11/2008 DOI: 10.1038/nature08391 EID: 2-s2.0-70349453919 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-70349453919&partnerID=MN8TOARS Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus Published: 30/11/2008 DOI: 10.1073/pnas.0910894106 EID: 2-s2.0-73949152966 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-73949152966&partnerID=MN8TOARS 2006 Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals Published: 30/11/2006 DOI: 10.1242/dev.02872 EID: 2-s2.0-34547483655 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547483655&partnerID=MN8TOARS Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon Published: 30/11/2006 DOI: 10.1242/dev.001461 EID: 2-s2.0-34848847165 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34848847165&partnerID=MN8TOARS Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries Published: 30/11/2006 DOI: 10.1016/j.ydbio.2006.08.022 EID: 2-s2.0-33846258014 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846258014&partnerID=MN8TOARS 2005 Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon Published: 30/11/2005 DOI: 10.1242/dev.02248 EID: 2-s2.0-32344446690 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-32344446690&partnerID=MN8TOARS 2003 Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Published: 30/11/2003 EID: 2-s2.0-3543006549 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3543006549&partnerID=MN8TOARS Endocytosis controls spreading and effective signaling range of Fgf8 protein Published: 30/11/2003 DOI: 10.1016/j.cub.2004.09.084 EID: 2-s2.0-6944255474 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-6944255474&partnerID=MN8TOARS Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary Published: 30/11/2003 EID: 2-s2.0-3543006549 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-3543006549&partnerID=MN8TOARS 2002 Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon Published: 30/11/2002 DOI: 10.1242/dev.00683 EID: 2-s2.0-0142181010 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0142181010&partnerID=MN8TOARS Erratum: Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (Development vol. 130 (4881-4893)) Published: 30/11/2002 EID: 2-s2.0-0242719723 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0242719723&partnerID=MN8TOARS Integrity of the Midbrain Region Is Required to Maintain the Diencephalic-Mesencephalic Boundary in Zebrafish no isthmus/pax2.1 Mutants Published: 30/11/2002 DOI: 10.1002/dvdy.10384 EID: 2-s2.0-0142222325 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0142222325&partnerID=MN8TOARS 2001 A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Published: 30/11/2001 EID: 2-s2.0-0036333606 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036333606&partnerID=MN8TOARS A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines Published: 30/11/2001 EID: 2-s2.0-0036333606 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036333606&partnerID=MN8TOARS 2000 Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain-hindbrain boundary development Published: 30/11/2000 DOI: 10.1002/gene.1047 EID: 2-s2.0-0034908357 URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034908357&partnerID=MN8TOARS 1999 Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons. Published: 30/11/1999 DOI: 10.1101/2023.02.17.528927 URL: