Prof Steven West Professor of Molecular Biology S.West@exeter.ac.uk CLES Groups: West Group University profile 0000-0002-7622-9050 Publications Publications 2021 ZC3H4 restricts non-coding transcription in human cells Published: 31/01/2021 OTHER-ID: PPR281477 DOI: 10.1101/2021.02.10.430684 URL: http://europepmc.org/abstract/PPR/PPR281477 2020 Integrator-Dependent and Allosteric/Intrinsic Mechanisms Ensure Efficient Termination of snRNA Transcription. Journal: Cell reports Published: 30/09/2020 PMID: 33113359 PMC: PMC7610016 DOI: 10.1016/j.celrep.2020.108319 URL: http://europepmc.org/abstract/med/33113359 Termination of Transcription by RNA Polymerase II: BOOM! Journal: Trends in genetics : TIG Published: 31/05/2020 PMID: 32527618 DOI: 10.1016/j.tig.2020.05.008 URL: http://europepmc.org/abstract/med/32527618 2019 A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes. Journal: Genes & development Published: 30/11/2019 PMID: 31805520 PMC: PMC6938672 DOI: 10.1101/gad.332833.119 URL: http://europepmc.org/abstract/med/31805520 Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control. Journal: Cell reports Published: 28/02/2019 PMID: 30840897 PMC: PMC6403362 DOI: 10.1016/j.celrep.2019.02.012 URL: http://europepmc.org/abstract/med/30840897 2018 An end in sight? Xrn2 and transcriptional termination by RNA polymerase II. Journal: Transcription Published: 31/07/2018 PMID: 30035655 PMC: PMC6150625 DOI: 10.1080/21541264.2018.1498708 URL: http://europepmc.org/abstract/med/30035655 2017 Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity. Journal: Genes & development Published: 31/12/2017 PMID: 29432121 PMC: PMC5830926 DOI: 10.1101/gad.308528.117 URL: http://europepmc.org/abstract/med/29432121 2015 Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs. Journal: Molecular and cellular biology Published: 31/03/2015 PMID: 25896913 PMC: PMC4456446 DOI: 10.1128/mcb.00123-15 URL: http://europepmc.org/abstract/med/25896913 2014 Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus. Journal: PloS one Published: 30/04/2014 PMID: 24796696 PMC: PMC4010461 DOI: 10.1371/journal.pone.0096174 URL: http://europepmc.org/abstract/med/24796696 2013 3′ end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. Journal: Genes & development Published: 31/12/2013 PMID: 24478330 PMC: PMC3937513 DOI: 10.1101/gad.231274.113 URL: http://europepmc.org/abstract/med/24478330 Splicing-coupled 3′ end formation requires a terminal splice acceptor site, but not intron excision. Journal: Nucleic acids research Published: 30/04/2013 PMID: 23716637 PMC: PMC3737548 DOI: 10.1093/nar/gkt446 URL: http://europepmc.org/abstract/med/23716637 2012 Co-transcriptional degradation of aberrant pre-mRNA by Xrn2. Journal: The EMBO journal Published: 31/03/2012 PMID: 22522706 PMC: PMC3365414 DOI: 10.1038/emboj.2012.101 URL: http://europepmc.org/abstract/med/22522706 2010 The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation. Journal: RNA (New York, N.Y.) Published: 31/10/2010 PMID: 21051505 PMC: PMC3004064 DOI: 10.1261/rna.2252511 URL: http://europepmc.org/abstract/med/21051505 2009 Transcriptional termination enhances protein expression in human cells. Journal: Molecular cell Published: 31/01/2009 PMID: 19217409 PMC: PMC2706331 DOI: 10.1016/j.molcel.2009.01.008 URL: http://europepmc.org/abstract/med/19217409 2008 Molecular dissection of mammalian RNA polymerase II transcriptional termination. Journal: Molecular cell Published: 29/02/2008 PMID: 18342606 PMC: PMC2288634 DOI: 10.1016/j.molcel.2007.12.019 URL: http://europepmc.org/abstract/med/18342606 2007 Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination. Journal: Nucleic acids research Published: 30/11/2007 PMID: 18086705 PMC: PMC2241900 DOI: 10.1093/nar/gkm1112 URL: http://europepmc.org/abstract/med/18086705 2006 Pause sites promote transcriptional termination of mammalian RNA polymerase II. Journal: Molecular and cellular biology Published: 30/04/2006 PMID: 16648491 PMC: PMC1488997 DOI: 10.1128/mcb.26.10.3986-3996.2006 URL: http://europepmc.org/abstract/med/16648491 Transcriptional termination sequences in the mouse serum albumin gene. Journal: RNA (New York, N.Y.) Published: 31/03/2006 PMID: 16581808 PMC: PMC1421085 DOI: 10.1261/rna.2232406 URL: http://europepmc.org/abstract/med/16581808 Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells. Journal: Molecular cell Published: 31/01/2006 PMID: 16455498 DOI: 10.1016/j.molcel.2005.12.008 URL: http://europepmc.org/abstract/med/16455498 2004 Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Journal: Nature Published: 31/10/2004 PMID: 15565159 DOI: 10.1038/nature03032 URL: http://europepmc.org/abstract/med/15565159 Human 5′ –> 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Journal: Nature Published: 31/10/2004 PMID: 15565158 DOI: 10.1038/nature03035 URL: http://europepmc.org/abstract/med/15565158