Publications
2021
ZC3H4 restricts non-coding transcription in human cells
Published: 31/01/2021OTHER-ID: PPR281477
DOI: 10.1101/2021.02.10.430684
URL: http://europepmc.org/abstract/PPR/PPR281477
2020
Integrator-Dependent and Allosteric/Intrinsic Mechanisms Ensure Efficient Termination of snRNA Transcription.
Journal:
Cell reports
Published:
30/09/2020
PMID: 33113359
PMC: PMC7610016
DOI: 10.1016/j.celrep.2020.108319
URL: http://europepmc.org/abstract/med/33113359
Termination of Transcription by RNA Polymerase II: BOOM!
Journal:
Trends in genetics : TIG
Published:
31/05/2020
PMID: 32527618
DOI: 10.1016/j.tig.2020.05.008
URL: http://europepmc.org/abstract/med/32527618
2019
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes.
Journal:
Genes & development
Published:
30/11/2019
PMID: 31805520
PMC: PMC6938672
DOI: 10.1101/gad.332833.119
URL: http://europepmc.org/abstract/med/31805520
Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control.
Journal:
Cell reports
Published:
28/02/2019
PMID: 30840897
PMC: PMC6403362
DOI: 10.1016/j.celrep.2019.02.012
URL: http://europepmc.org/abstract/med/30840897
2018
An end in sight? Xrn2 and transcriptional termination by RNA polymerase II.
Journal:
Transcription
Published:
31/07/2018
PMID: 30035655
PMC: PMC6150625
DOI: 10.1080/21541264.2018.1498708
URL: http://europepmc.org/abstract/med/30035655
2017
Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.
Journal:
Genes & development
Published:
31/12/2017
PMID: 29432121
PMC: PMC5830926
DOI: 10.1101/gad.308528.117
URL: http://europepmc.org/abstract/med/29432121
2015
Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs.
Journal:
Molecular and cellular biology
Published:
31/03/2015
PMID: 25896913
PMC: PMC4456446
DOI: 10.1128/mcb.00123-15
URL: http://europepmc.org/abstract/med/25896913
2014
Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.
Journal:
PloS one
Published:
30/04/2014
PMID: 24796696
PMC: PMC4010461
DOI: 10.1371/journal.pone.0096174
URL: http://europepmc.org/abstract/med/24796696
2013
3′ end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells.
Journal:
Genes & development
Published:
31/12/2013
PMID: 24478330
PMC: PMC3937513
DOI: 10.1101/gad.231274.113
URL: http://europepmc.org/abstract/med/24478330
Splicing-coupled 3′ end formation requires a terminal splice acceptor site, but not intron excision.
Journal:
Nucleic acids research
Published:
30/04/2013
PMID: 23716637
PMC: PMC3737548
DOI: 10.1093/nar/gkt446
URL: http://europepmc.org/abstract/med/23716637
2012
Co-transcriptional degradation of aberrant pre-mRNA by Xrn2.
Journal:
The EMBO journal
Published:
31/03/2012
PMID: 22522706
PMC: PMC3365414
DOI: 10.1038/emboj.2012.101
URL: http://europepmc.org/abstract/med/22522706
2010
The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation.
Journal:
RNA (New York, N.Y.)
Published:
31/10/2010
PMID: 21051505
PMC: PMC3004064
DOI: 10.1261/rna.2252511
URL: http://europepmc.org/abstract/med/21051505
2009
Transcriptional termination enhances protein expression in human cells.
Journal:
Molecular cell
Published:
31/01/2009
PMID: 19217409
PMC: PMC2706331
DOI: 10.1016/j.molcel.2009.01.008
URL: http://europepmc.org/abstract/med/19217409
2008
Molecular dissection of mammalian RNA polymerase II transcriptional termination.
Journal:
Molecular cell
Published:
29/02/2008
PMID: 18342606
PMC: PMC2288634
DOI: 10.1016/j.molcel.2007.12.019
URL: http://europepmc.org/abstract/med/18342606
2007
Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination.
Journal:
Nucleic acids research
Published:
30/11/2007
PMID: 18086705
PMC: PMC2241900
DOI: 10.1093/nar/gkm1112
URL: http://europepmc.org/abstract/med/18086705
2006
Pause sites promote transcriptional termination of mammalian RNA polymerase II.
Journal:
Molecular and cellular biology
Published:
30/04/2006
PMID: 16648491
PMC: PMC1488997
DOI: 10.1128/mcb.26.10.3986-3996.2006
URL: http://europepmc.org/abstract/med/16648491
Transcriptional termination sequences in the mouse serum albumin gene.
Journal:
RNA (New York, N.Y.)
Published:
31/03/2006
PMID: 16581808
PMC: PMC1421085
DOI: 10.1261/rna.2232406
URL: http://europepmc.org/abstract/med/16581808
Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.
Journal:
Molecular cell
Published:
31/01/2006
PMID: 16455498
DOI: 10.1016/j.molcel.2005.12.008
URL: http://europepmc.org/abstract/med/16455498
2004
Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination.
Journal:
Nature
Published:
31/10/2004
PMID: 15565159
DOI: 10.1038/nature03032
URL: http://europepmc.org/abstract/med/15565159
Human 5′ –> 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
Journal:
Nature
Published:
31/10/2004
PMID: 15565158
DOI: 10.1038/nature03035
URL: http://europepmc.org/abstract/med/15565158