Dr Tom Piers Postdoctoral Research Fellow T.Piers@exeter.ac.uk CLES Groups: Scholpp Group University profile 0000-0003-4353-3897 Publications Publications 2023 Microglia produce the amyloidogenic ABri peptide in familial British dementia Published: 31/05/2023 PPR: PPR682883 DOI: 10.1101/2023.06.27.546552 URL: http://europepmc.org/abstract/PPR/PPR682883 Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons. Published: 17/02/2023 DOI: 10.1101/2023.02.17.528927 URL: https://doi.org/10.1101/2023.02.17.528927 2022 Alzheimer’s disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Journal: Glia Published: 30/11/2022 PMID: 36480007 DOI: 10.1002/glia.24318 URL: http://europepmc.org/abstract/med/36480007 Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model. Journal: Glia Published: 30/11/2022 PMID: 36571248 DOI: 10.1002/glia.24325 URL: http://europepmc.org/abstract/med/36571248 Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence Published: 30/04/2022 PPR: PPR496847 DOI: 10.1101/2022.05.23.493044 URL: http://europepmc.org/abstract/PPR/PPR496847 2021 A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene. Journal: Brain : a journal of neurology Published: 30/11/2021 PMID: 34619763 PMC: PMC8500089 DOI: 10.1093/brain/awab337 URL: http://europepmc.org/abstract/med/34619763 Ca2+/calmodulin-stimulated Adenylyl Cyclases are Required for the Potentiating Effect of Glucocorticoid Exposure in the Rat Hippocampal Synapse Published: 30/09/2021 PPR: PPR410326 DOI: 10.21203/rs.3.rs-923210/v1 URL: http://europepmc.org/abstract/PPR/PPR410326 Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons. Published: 30/06/2021 PPR: PPR372004 DOI: 10.1101/2021.07.19.452610 URL: http://europepmc.org/abstract/PPR/PPR372004 Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome. Journal: Scientific reports Published: 31/05/2021 PMID: 34172778 PMC: PMC8233372 DOI: 10.1038/s41598-021-91207-1 URL: http://europepmc.org/abstract/med/34172778 Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells. Journal: Neurochemistry international Published: 30/04/2021 PMID: 34004238 PMC: PMC7610942 DOI: 10.1016/j.neuint.2021.105070 URL: http://europepmc.org/abstract/med/34004238 Calcium/Calmodulin-Stimulatable Adenylyl cyclases are required for the potentiating effect of acute glucocorticoid exposure in the hippocampal synapse Published: 28/02/2021 PPR: PPR291922 DOI: 10.21203/rs.3.rs-244813/v1 URL: http://europepmc.org/abstract/PPR/PPR291922 Genetic variability associated withOAS1expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes Published: 28/02/2021 PPR: PPR299491 DOI: 10.1101/2021.03.16.435702 URL: http://europepmc.org/abstract/PPR/PPR299491 The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles. Journal: Brain communications Published: 31/01/2021 PMID: 34704019 PMC: PMC8244649 DOI: 10.1093/braincomms/fcab009 URL: http://europepmc.org/abstract/med/34704019 2020 Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Journal: Human molecular genetics Published: 31/10/2020 PMID: 32959884 PMC: PMC7689298 DOI: 10.1093/hmg/ddaa209 URL: http://europepmc.org/abstract/med/32959884 Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome Published: 31/08/2020 PPR: PPR212416 DOI: 10.1101/2020.09.08.288043 URL: http://europepmc.org/abstract/PPR/PPR212416 2019 A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Published: 30/11/2019 PMID: 31907987 PMC: PMC7027848 DOI: 10.1096/fj.201902447r URL: http://europepmc.org/abstract/med/31907987 A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC–derived microglia Published: 31/08/2019 PPR: PPR92108 DOI: 10.1101/766089 URL: http://europepmc.org/abstract/PPR/PPR92108 2018 Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity. Journal: Frontiers in cellular neuroscience Published: 31/10/2018 PMID: 30524237 PMC: PMC6257202 DOI: 10.3389/fncel.2018.00404 URL: http://europepmc.org/abstract/med/30524237 Trem2promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions Published: 30/09/2018 PPR: PPR59445 DOI: 10.1101/449884 URL: http://europepmc.org/abstract/PPR/PPR59445 The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Journal: Molecular neurodegeneration Published: 31/08/2018 PMID: 30185230 PMC: PMC6126019 DOI: 10.1186/s13024-018-0280-6 URL: http://europepmc.org/abstract/med/30185230 Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis. Journal: Cell reports Published: 31/07/2018 PMID: 30157425 PMC: PMC6130048 DOI: 10.1016/j.celrep.2018.07.094 URL: http://europepmc.org/abstract/med/30157425 Modelling microglial function with induced pluripotent stem cells: an update. Journal: Nature reviews. Neuroscience Published: 31/07/2018 PMID: 29977068 DOI: 10.1038/s41583-018-0030-3 URL: http://europepmc.org/abstract/med/29977068 Postsynaptic p47phox regulates long-term depression in the hippocampus. Journal: Cell discovery Published: 31/07/2018 PMID: 30181899 PMC: PMC6110736 DOI: 10.1038/s41421-018-0046-x URL: http://europepmc.org/abstract/med/30181899 2017 Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. Journal: Pharmacological research Published: 31/03/2017 PMID: 28416463 DOI: 10.1016/j.phrs.2017.04.015 URL: http://europepmc.org/abstract/med/28416463 2015 Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Journal: Pharmacological research Published: 30/11/2015 PMID: 26687096 PMC: PMC4773404 DOI: 10.1016/j.phrs.2015.12.008 URL: http://europepmc.org/abstract/med/26687096 Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson’s disease. Journal: Neuropathology and applied neurobiology Published: 31/08/2015 PMID: 26300398 DOI: 10.1111/nan.12263 URL: http://europepmc.org/abstract/med/26300398 Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester. Journal: Journal of visualized experiments : JoVE Published: 30/06/2015 PMID: 26275019 PMC: PMC4545156 DOI: 10.3791/52983 URL: http://europepmc.org/abstract/med/26275019 Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus. Journal: Scientific reports Published: 31/05/2015 PMID: 26055072 PMC: PMC4460729 DOI: 10.1038/srep10934 URL: http://europepmc.org/abstract/med/26055072 Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer’s disease. Journal: Frontiers in neuroscience Published: 28/02/2015 PMID: 25852450 PMC: PMC4360710 DOI: 10.3389/fnins.2015.00047 URL: http://europepmc.org/abstract/med/25852450 Tau phosphorylation at serine 396 residue is required for hippocampal LTD. Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience Published: 28/02/2015 PMID: 25810511 PMC: PMC4389589 DOI: 10.1523/jneurosci.2842-14.2015 URL: http://europepmc.org/abstract/med/25810511 2013 Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences Published: 30/11/2013 PMID: 24298146 PMC: PMC3843876 DOI: 10.1098/rstb.2013.0144 URL: http://europepmc.org/abstract/med/24298146 Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. Journal: Brain : a journal of neurology Published: 31/10/2013 PMID: 24271563 PMC: PMC3859225 DOI: 10.1093/brain/awt293 URL: http://europepmc.org/abstract/med/24271563 Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis. Journal: Brain : a journal of neurology Published: 28/02/2013 PMID: 23518709 DOI: 10.1093/brain/awt041 URL: http://europepmc.org/abstract/med/23518709 2012 Translational Concepts of mGluR5 in Synaptic Diseases of the Brain. Journal: Frontiers in pharmacology Published: 31/10/2012 PMID: 23205012 PMC: PMC3506921 DOI: 10.3389/fphar.2012.00199 URL: http://europepmc.org/abstract/med/23205012 2011 Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection. Journal: Neuroscience letters Published: 30/09/2011 PMID: 22015768 DOI: 10.1016/j.neulet.2011.10.007 URL: http://europepmc.org/abstract/med/22015768 2009 Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer’s disease. Journal: Life sciences Published: 31/01/2009 PMID: 19302808 DOI: 10.1016/j.lfs.2009.01.019 URL: http://europepmc.org/abstract/med/19302808