Dr Tom Piers

Postdoctoral Research Fellow

T.Piers@exeter.ac.uk

CLES

Groups: Scholpp Group

University profile

0000-0003-4353-3897

Publications

2023

Microglia produce the amyloidogenic ABri peptide in familial British dementia

Published: 31/05/2023
PPR: PPR682883
DOI: 10.1101/2023.06.27.546552
URL: http://europepmc.org/abstract/PPR/PPR682883

Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons.

Published: 17/02/2023
DOI: 10.1101/2023.02.17.528927
URL: https://doi.org/10.1101/2023.02.17.528927

2022

Alzheimer’s disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Journal: Glia

Published: 30/11/2022
PMID: 36480007
DOI: 10.1002/glia.24318
URL: http://europepmc.org/abstract/med/36480007

Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model.

Journal: Glia

Published: 30/11/2022
PMID: 36571248
DOI: 10.1002/glia.24325
URL: http://europepmc.org/abstract/med/36571248

Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence

Published: 30/04/2022
PPR: PPR496847
DOI: 10.1101/2022.05.23.493044
URL: http://europepmc.org/abstract/PPR/PPR496847

2021

A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene.

Journal: Brain : a journal of neurology

Published: 30/11/2021
PMID: 34619763
PMC: PMC8500089
DOI: 10.1093/brain/awab337
URL: http://europepmc.org/abstract/med/34619763

Ca2+/calmodulin-stimulated Adenylyl Cyclases are Required for the Potentiating Effect of Glucocorticoid Exposure in the Rat Hippocampal Synapse

Published: 30/09/2021
PPR: PPR410326
DOI: 10.21203/rs.3.rs-923210/v1
URL: http://europepmc.org/abstract/PPR/PPR410326

Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons.

Published: 30/06/2021
PPR: PPR372004
DOI: 10.1101/2021.07.19.452610
URL: http://europepmc.org/abstract/PPR/PPR372004

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.

Journal: Scientific reports

Published: 31/05/2021
PMID: 34172778
PMC: PMC8233372
DOI: 10.1038/s41598-021-91207-1
URL: http://europepmc.org/abstract/med/34172778

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.

Journal: Neurochemistry international

Published: 30/04/2021
PMID: 34004238
PMC: PMC7610942
DOI: 10.1016/j.neuint.2021.105070
URL: http://europepmc.org/abstract/med/34004238

Calcium/Calmodulin-Stimulatable Adenylyl cyclases are required for the potentiating effect of acute glucocorticoid exposure in the hippocampal synapse

Published: 28/02/2021
PPR: PPR291922
DOI: 10.21203/rs.3.rs-244813/v1
URL: http://europepmc.org/abstract/PPR/PPR291922

Genetic variability associated withOAS1expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes

Published: 28/02/2021
PPR: PPR299491
DOI: 10.1101/2021.03.16.435702
URL: http://europepmc.org/abstract/PPR/PPR299491

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.

Journal: Brain communications

Published: 31/01/2021
PMID: 34704019
PMC: PMC8244649
DOI: 10.1093/braincomms/fcab009
URL: http://europepmc.org/abstract/med/34704019

2020

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.

Journal: Human molecular genetics

Published: 31/10/2020
PMID: 32959884
PMC: PMC7689298
DOI: 10.1093/hmg/ddaa209
URL: http://europepmc.org/abstract/med/32959884

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

Published: 31/08/2020
PPR: PPR212416
DOI: 10.1101/2020.09.08.288043
URL: http://europepmc.org/abstract/PPR/PPR212416

2019

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Published: 30/11/2019
PMID: 31907987
PMC: PMC7027848
DOI: 10.1096/fj.201902447r
URL: http://europepmc.org/abstract/med/31907987

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC–derived microglia

Published: 31/08/2019
PPR: PPR92108
DOI: 10.1101/766089
URL: http://europepmc.org/abstract/PPR/PPR92108

2018

Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity.

Journal: Frontiers in cellular neuroscience

Published: 31/10/2018
PMID: 30524237
PMC: PMC6257202
DOI: 10.3389/fncel.2018.00404
URL: http://europepmc.org/abstract/med/30524237

Trem2promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Published: 30/09/2018
PPR: PPR59445
DOI: 10.1101/449884
URL: http://europepmc.org/abstract/PPR/PPR59445

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.

Journal: Molecular neurodegeneration

Published: 31/08/2018
PMID: 30185230
PMC: PMC6126019
DOI: 10.1186/s13024-018-0280-6
URL: http://europepmc.org/abstract/med/30185230

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.

Journal: Cell reports

Published: 31/07/2018
PMID: 30157425
PMC: PMC6130048
DOI: 10.1016/j.celrep.2018.07.094
URL: http://europepmc.org/abstract/med/30157425

Modelling microglial function with induced pluripotent stem cells: an update.

Journal: Nature reviews. Neuroscience

Published: 31/07/2018
PMID: 29977068
DOI: 10.1038/s41583-018-0030-3
URL: http://europepmc.org/abstract/med/29977068

Postsynaptic p47phox regulates long-term depression in the hippocampus.

Journal: Cell discovery

Published: 31/07/2018
PMID: 30181899
PMC: PMC6110736
DOI: 10.1038/s41421-018-0046-x
URL: http://europepmc.org/abstract/med/30181899

2017

Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus.

Journal: Pharmacological research

Published: 31/03/2017
PMID: 28416463
DOI: 10.1016/j.phrs.2017.04.015
URL: http://europepmc.org/abstract/med/28416463

2015

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF).

Journal: Pharmacological research

Published: 30/11/2015
PMID: 26687096
PMC: PMC4773404
DOI: 10.1016/j.phrs.2015.12.008
URL: http://europepmc.org/abstract/med/26687096

Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson’s disease.

Journal: Neuropathology and applied neurobiology

Published: 31/08/2015
PMID: 26300398
DOI: 10.1111/nan.12263
URL: http://europepmc.org/abstract/med/26300398

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester.

Journal: Journal of visualized experiments : JoVE

Published: 30/06/2015
PMID: 26275019
PMC: PMC4545156
DOI: 10.3791/52983
URL: http://europepmc.org/abstract/med/26275019

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.

Journal: Scientific reports

Published: 31/05/2015
PMID: 26055072
PMC: PMC4460729
DOI: 10.1038/srep10934
URL: http://europepmc.org/abstract/med/26055072

Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer’s disease.

Journal: Frontiers in neuroscience

Published: 28/02/2015
PMID: 25852450
PMC: PMC4360710
DOI: 10.3389/fnins.2015.00047
URL: http://europepmc.org/abstract/med/25852450

Tau phosphorylation at serine 396 residue is required for hippocampal LTD.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: 28/02/2015
PMID: 25810511
PMC: PMC4389589
DOI: 10.1523/jneurosci.2842-14.2015
URL: http://europepmc.org/abstract/med/25810511

2013

Microtubule-associated protein tau is essential for long-term depression in the hippocampus.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Published: 30/11/2013
PMID: 24298146
PMC: PMC3843876
DOI: 10.1098/rstb.2013.0144
URL: http://europepmc.org/abstract/med/24298146

Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.

Journal: Brain : a journal of neurology

Published: 31/10/2013
PMID: 24271563
PMC: PMC3859225
DOI: 10.1093/brain/awt293
URL: http://europepmc.org/abstract/med/24271563

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.

Journal: Brain : a journal of neurology

Published: 28/02/2013
PMID: 23518709
DOI: 10.1093/brain/awt041
URL: http://europepmc.org/abstract/med/23518709

2012

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain.

Journal: Frontiers in pharmacology

Published: 31/10/2012
PMID: 23205012
PMC: PMC3506921
DOI: 10.3389/fphar.2012.00199
URL: http://europepmc.org/abstract/med/23205012

2011

Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection.

Journal: Neuroscience letters

Published: 30/09/2011
PMID: 22015768
DOI: 10.1016/j.neulet.2011.10.007
URL: http://europepmc.org/abstract/med/22015768

2009

Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer’s disease.

Journal: Life sciences

Published: 31/01/2009
PMID: 19302808
DOI: 10.1016/j.lfs.2009.01.019
URL: http://europepmc.org/abstract/med/19302808

Dr Tom Piers

Postdoctoral Research Fellow

Publications

2023

Microglia produce the amyloidogenic ABri peptide in familial British dementia

Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons.

2022

Alzheimer’s disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model.

Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence

2021

A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene.

Ca2+/calmodulin-stimulated Adenylyl Cyclases are Required for the Potentiating Effect of Glucocorticoid Exposure in the Rat Hippocampal Synapse

Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons.

Microglial﻿ signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.

Calcium/Calmodulin-Stimulatable Adenylyl cyclases are required for the potentiating effect of acute glucocorticoid exposure in the hippocampal synapse

Genetic variability associated withOAS1expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.

2020

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.

Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome

2019

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC–derived microglia

2018

Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity.

Trem2promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.

Modelling microglial function with induced pluripotent stem cells: an update.

Postsynaptic p47phox regulates long-term depression in the hippocampus.

2017

Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus.

2015

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF).

Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson’s disease.

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester.

Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.

Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer’s disease.

Tau phosphorylation at serine 396 residue is required for hippocampal LTD.

2013

Microtubule-associated protein tau is essential for long-term depression in the hippocampus.

Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.

2012

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain.

2011

Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection.

2009

Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer’s disease.

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.