
Publications
2023
Microglia produce the amyloidogenic ABri peptide in familial British dementia
Published: 31/05/2023PPR: PPR682883
DOI: 10.1101/2023.06.27.546552
URL: http://europepmc.org/abstract/PPR/PPR682883
Wnt-7a-positive dendritic cytonemes induce synaptogenesis in cortical neurons.
Published: 17/02/2023DOI: 10.1101/2023.02.17.528927
URL: https://doi.org/10.1101/2023.02.17.528927
2022
Alzheimer’s disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Journal:
Glia
Published:
30/11/2022
PMID: 36480007
DOI: 10.1002/glia.24318
URL: http://europepmc.org/abstract/med/36480007
Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model.
Journal:
Glia
Published:
30/11/2022
PMID: 36571248
DOI: 10.1002/glia.24325
URL: http://europepmc.org/abstract/med/36571248
Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence
Published: 30/04/2022PPR: PPR496847
DOI: 10.1101/2022.05.23.493044
URL: http://europepmc.org/abstract/PPR/PPR496847
2021
A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene.
Journal:
Brain : a journal of neurology
Published:
30/11/2021
PMID: 34619763
PMC: PMC8500089
DOI: 10.1093/brain/awab337
URL: http://europepmc.org/abstract/med/34619763
Ca2+/calmodulin-stimulated Adenylyl Cyclases are Required for the Potentiating Effect of Glucocorticoid Exposure in the Rat Hippocampal Synapse
Published: 30/09/2021PPR: PPR410326
DOI: 10.21203/rs.3.rs-923210/v1
URL: http://europepmc.org/abstract/PPR/PPR410326
Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons.
Published: 30/06/2021PPR: PPR372004
DOI: 10.1101/2021.07.19.452610
URL: http://europepmc.org/abstract/PPR/PPR372004
Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Journal:
Scientific reports
Published:
31/05/2021
PMID: 34172778
PMC: PMC8233372
DOI: 10.1038/s41598-021-91207-1
URL: http://europepmc.org/abstract/med/34172778
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Journal:
Neurochemistry international
Published:
30/04/2021
PMID: 34004238
PMC: PMC7610942
DOI: 10.1016/j.neuint.2021.105070
URL: http://europepmc.org/abstract/med/34004238
Calcium/Calmodulin-Stimulatable Adenylyl cyclases are required for the potentiating effect of acute glucocorticoid exposure in the hippocampal synapse
Published: 28/02/2021PPR: PPR291922
DOI: 10.21203/rs.3.rs-244813/v1
URL: http://europepmc.org/abstract/PPR/PPR291922
Genetic variability associated withOAS1expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes
Published: 28/02/2021PPR: PPR299491
DOI: 10.1101/2021.03.16.435702
URL: http://europepmc.org/abstract/PPR/PPR299491
The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.
Journal:
Brain communications
Published:
31/01/2021
PMID: 34704019
PMC: PMC8244649
DOI: 10.1093/braincomms/fcab009
URL: http://europepmc.org/abstract/med/34704019
2020
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
Journal:
Human molecular genetics
Published:
31/10/2020
PMID: 32959884
PMC: PMC7689298
DOI: 10.1093/hmg/ddaa209
URL: http://europepmc.org/abstract/med/32959884
Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome
Published: 31/08/2020PPR: PPR212416
DOI: 10.1101/2020.09.08.288043
URL: http://europepmc.org/abstract/PPR/PPR212416
2019
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Published:
30/11/2019
PMID: 31907987
PMC: PMC7027848
DOI: 10.1096/fj.201902447r
URL: http://europepmc.org/abstract/med/31907987
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC–derived microglia
Published: 31/08/2019PPR: PPR92108
DOI: 10.1101/766089
URL: http://europepmc.org/abstract/PPR/PPR92108
2018
Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity.
Journal:
Frontiers in cellular neuroscience
Published:
31/10/2018
PMID: 30524237
PMC: PMC6257202
DOI: 10.3389/fncel.2018.00404
URL: http://europepmc.org/abstract/med/30524237
Trem2promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
Published: 30/09/2018PPR: PPR59445
DOI: 10.1101/449884
URL: http://europepmc.org/abstract/PPR/PPR59445
The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Journal:
Molecular neurodegeneration
Published:
31/08/2018
PMID: 30185230
PMC: PMC6126019
DOI: 10.1186/s13024-018-0280-6
URL: http://europepmc.org/abstract/med/30185230
Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Journal:
Cell reports
Published:
31/07/2018
PMID: 30157425
PMC: PMC6130048
DOI: 10.1016/j.celrep.2018.07.094
URL: http://europepmc.org/abstract/med/30157425
Modelling microglial function with induced pluripotent stem cells: an update.
Journal:
Nature reviews. Neuroscience
Published:
31/07/2018
PMID: 29977068
DOI: 10.1038/s41583-018-0030-3
URL: http://europepmc.org/abstract/med/29977068
Postsynaptic p47phox regulates long-term depression in the hippocampus.
Journal:
Cell discovery
Published:
31/07/2018
PMID: 30181899
PMC: PMC6110736
DOI: 10.1038/s41421-018-0046-x
URL: http://europepmc.org/abstract/med/30181899
2017
Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus.
Journal:
Pharmacological research
Published:
31/03/2017
PMID: 28416463
DOI: 10.1016/j.phrs.2017.04.015
URL: http://europepmc.org/abstract/med/28416463
2015
Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF).
Journal:
Pharmacological research
Published:
30/11/2015
PMID: 26687096
PMC: PMC4773404
DOI: 10.1016/j.phrs.2015.12.008
URL: http://europepmc.org/abstract/med/26687096
Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson’s disease.
Journal:
Neuropathology and applied neurobiology
Published:
31/08/2015
PMID: 26300398
DOI: 10.1111/nan.12263
URL: http://europepmc.org/abstract/med/26300398
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester.
Journal:
Journal of visualized experiments : JoVE
Published:
30/06/2015
PMID: 26275019
PMC: PMC4545156
DOI: 10.3791/52983
URL: http://europepmc.org/abstract/med/26275019
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.
Journal:
Scientific reports
Published:
31/05/2015
PMID: 26055072
PMC: PMC4460729
DOI: 10.1038/srep10934
URL: http://europepmc.org/abstract/med/26055072
Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer’s disease.
Journal:
Frontiers in neuroscience
Published:
28/02/2015
PMID: 25852450
PMC: PMC4360710
DOI: 10.3389/fnins.2015.00047
URL: http://europepmc.org/abstract/med/25852450
Tau phosphorylation at serine 396 residue is required for hippocampal LTD.
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Published:
28/02/2015
PMID: 25810511
PMC: PMC4389589
DOI: 10.1523/jneurosci.2842-14.2015
URL: http://europepmc.org/abstract/med/25810511
2013
Microtubule-associated protein tau is essential for long-term depression in the hippocampus.
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Published:
30/11/2013
PMID: 24298146
PMC: PMC3843876
DOI: 10.1098/rstb.2013.0144
URL: http://europepmc.org/abstract/med/24298146
Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.
Journal:
Brain : a journal of neurology
Published:
31/10/2013
PMID: 24271563
PMC: PMC3859225
DOI: 10.1093/brain/awt293
URL: http://europepmc.org/abstract/med/24271563
Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.
Journal:
Brain : a journal of neurology
Published:
28/02/2013
PMID: 23518709
DOI: 10.1093/brain/awt041
URL: http://europepmc.org/abstract/med/23518709
2012
Translational Concepts of mGluR5 in Synaptic Diseases of the Brain.
Journal:
Frontiers in pharmacology
Published:
31/10/2012
PMID: 23205012
PMC: PMC3506921
DOI: 10.3389/fphar.2012.00199
URL: http://europepmc.org/abstract/med/23205012
2011
Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection.
Journal:
Neuroscience letters
Published:
30/09/2011
PMID: 22015768
DOI: 10.1016/j.neulet.2011.10.007
URL: http://europepmc.org/abstract/med/22015768
2009
Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer’s disease.
Journal:
Life sciences
Published:
31/01/2009
PMID: 19302808
DOI: 10.1016/j.lfs.2009.01.019
URL: http://europepmc.org/abstract/med/19302808