Prof Brian Hendrich Professor b.d.hendrich@exeter.ac.uk 01392 722346 Living Systems Institute, Sir Steve Smith Building T02.12 Groups: Hendrich Group University profile 0000-0002-0231-3073 Publications Publications 2025 The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements Published: 29/08/2025 DOI: 10.1101/2025.08.29.672645 URL: https://doi.org/10.1101/2025.08.29.672645 2023 The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells. Journal: The Company of Biologists Published: 19/12/2023 DOI: 10.17863/cam.104622 URL: Imaging data from “Live-cell 3D single-molecule tracking reveals modulation of enhancer dynamics by NuRD” Journal: OpenAlex Published: 30/05/2023 DOI: 10.60692/9rq3n-1nd27 URL: The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells Published: 10/02/2023 DOI: 10.1101/2023.02.09.527610 URL: https://doi.org/10.1101/2023.02.09.527610 2020 Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by the nucleosome remodelling and deacetylation complex. Journal: Elsevier BV Published: 05/06/2020 DOI: 10.17863/cam.53249 URL: Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics Published: 31/03/2020 OTHER-ID: PPR139209 DOI: 10.1101/2020.04.03.003178 URL: http://europepmc.org/abstract/PPR/PPR139209 Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRD Published: 05/02/2020 DOI: 10.1101/2020.02.05.935544 URL: https://doi.org/10.1101/2020.02.05.935544 2019 The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment. Journal: Springer Science and Business Media LLC Published: 12/04/2019 DOI: 10.17863/cam.38722 URL: 2018 PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Journal: Nature communications Published: 30/09/2018 PMID: 30327463 PMC: PMC6191444 DOI: 10.1038/s41467-018-06665-5 URL: http://europepmc.org/abstract/med/30327463 Subunit redundancy within the NuRD complex ensures fidelity of ES cell lineage commitment Published: 30/06/2018 OTHER-ID: PPR7631 DOI: 10.1101/362988 URL: http://europepmc.org/abstract/PPR/PPR7631 The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression. Journal: Molecular cell Published: 31/05/2018 PMID: 30008319 PMC: PMC6039721 DOI: 10.1016/j.molcel.2018.06.003 URL: http://europepmc.org/abstract/med/30008319 FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells. Journal: Nature communications Published: 31/05/2018 PMID: 29955052 PMC: PMC6023872 DOI: 10.1038/s41467-018-04486-0 URL: http://europepmc.org/abstract/med/29955052 Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell. Journal: Apollo - University of Cambridge Repository Published: 28/02/2018 DOI: 10.17863/CAM.17117 URL: NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment Journal: Apollo - University of Cambridge Repository Published: 12/01/2018 DOI: 10.17863/CAM.17424 URL: 2017 Chromatin Remodelling Proteins and Cell Fate Decisions in Mammalian Preimplantation Development. Journal: Advances in anatomy, embryology, and cell biology Published: 31/12/2017 PMID: 29177761 DOI: 10.1007/978-3-319-63187-5_2 URL: http://europepmc.org/abstract/med/29177761 Nucleosome occupancy during NuRD complex induction Published: 30/11/2017 OTHER-ID: E-MTAB-6807 URL: Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program Journal: Journal of Experimental Medicine Published: 02/10/2017 DOI: 10.1084/jem.20161827 URL: https://doi.org/10.1084/jem.20161827 Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cells Published: 27/09/2017 DOI: 10.1101/194852 URL: https://doi.org/10.1101/194852 The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules Journal: Apollo - University of Cambridge Repository Published: 20/04/2017 DOI: 10.17863/CAM.9088 URL: A high-resolution map of transcriptional repression Journal: eLife Published: 20/03/2017 DOI: 10.7554/eLife.22767 URL: https://doi.org/10.7554/eLife.22767 3D structure of individual mammalian genomes studied by single cell Hi-C Journal: Apollo - University of Cambridge Repository Published: 06/03/2017 DOI: 10.17863/CAM.8182 URL: 3D structures of individual mammalian genomes studied by single-cell Hi-C. Published: 28/02/2017 PMID: 28289288 DOI: 10.1038/nature21429 URL: http://europepmc.org/abstract/med/28289288 2016 The Nucleosome Remodelling and Deacetylation complex restricts Mediator access to enhancers to control transcription Published: 31/12/2016 OTHER-ID: PPR7110 DOI: 10.1101/103192 URL: http://europepmc.org/abstract/PPR/PPR7110 The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules. Published: 30/06/2016 PMID: 27117189 PMC: PMC4942838 DOI: 10.1016/j.jmb.2016.04.025 URL: http://europepmc.org/abstract/med/27117189 Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex. Journal: Development Published: 01/01/2016 DOI: 10.1242/dev.139113 URL: https://doi.org/10.1242/dev.139113 2015 Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Published: 31/07/2015 PMID: 26116663 PMC: PMC4529036 DOI: 10.1242/dev.125450 URL: http://europepmc.org/abstract/med/26116663 The function of chromatin modifiers in lineage commitment and cell fate specification. Published: 30/04/2015 PMID: 25354247 PMC: PMC4508967 DOI: 10.1111/febs.13132 URL: http://europepmc.org/abstract/med/25354247 2014 Mbd3 and deterministic reprogramming Published: 31/12/2014 OTHER-ID: PPR35426 DOI: 10.1101/013904 URL: http://europepmc.org/abstract/PPR/PPR35426 The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex. Published: 30/11/2014 PMID: 25934499 PMC: PMC4432814 DOI: 10.1186/s13064-015-0040-z URL: http://europepmc.org/abstract/med/25934499 MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner. Published: 30/06/2014 PMID: 24835571 PMC: PMC4082719 DOI: 10.1016/j.stem.2014.04.019 URL: http://europepmc.org/abstract/med/24835571 2013 CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now. Published: 31/05/2013 PMID: 23697937 PMC: PMC3685327 DOI: 10.1042/bst20130027 URL: http://europepmc.org/abstract/med/23697937 Transcriptional repressors: multifaceted regulators of gene expression. Published: 31/01/2013 PMID: 23293282 DOI: 10.1242/dev.083105 URL: http://europepmc.org/abstract/med/23293282 2012 NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Published: 30/04/2012 PMID: 22560079 PMC: PMC3402183 DOI: 10.1016/j.stem.2012.02.020 URL: http://europepmc.org/abstract/med/22560079 NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate. Published: 31/03/2012 PMID: 23213424 PMC: PMC3509455 DOI: 10.1242/bio.2012513 URL: http://europepmc.org/abstract/med/23213424 Sin3a is essential for the genome integrity and viability of pluripotent cells. Published: 29/02/2012 PMID: 22206758 PMC: PMC3334623 DOI: 10.1016/j.ydbio.2011.12.019 URL: http://europepmc.org/abstract/med/22206758 NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. Published: 31/01/2012 PMID: 22139358 PMC: PMC3273378 DOI: 10.1038/emboj.2011.431 URL: http://europepmc.org/abstract/med/22139358 2011 The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Published: 30/11/2011 PMID: 22101514 PMC: PMC3242072 DOI: 10.1038/ncb2385 URL: http://europepmc.org/abstract/med/22101514 MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line. Published: 30/11/2011 PMID: 23112857 PMC: PMC3480415 DOI: 10.1371/journal.pone.0047848 URL: http://europepmc.org/abstract/med/23112857 NuRD-mediated gene repression in mouse embryonic stem cells Published: 30/11/2011 OTHER-ID: E-MTAB-888 URL: 2010 c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. Published: 31/12/2010 PMID: 21196933 DOI: 10.1038/nature09607 URL: http://europepmc.org/abstract/med/21196933 2008 The methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation. Journal: PloS one Published: 31/12/2008 PMID: 19177165 PMC: PMC2627903 DOI: 10.1371/journal.pone.0004315 URL: http://europepmc.org/abstract/med/19177165 Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Journal: The international journal of biochemistry & cell biology Published: 31/07/2008 PMID: 18775506 PMC: PMC2880436 DOI: 10.1016/j.biocel.2008.07.022 URL: http://europepmc.org/abstract/med/18775506 2007 Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Journal: Molecular and cellular biology Published: 28/02/2007 PMID: 17353271 PMC: PMC1900000 DOI: 10.1128/MCB.02204-06 URL: http://europepmc.org/abstract/med/17353271 Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Journal: Development (Cambridge, England) Published: 31/01/2007 PMID: 17287250 DOI: 10.1242/dev.02802 URL: http://europepmc.org/abstract/med/17287250 2006 The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Journal: Nature cell biology Published: 31/01/2006 PMID: 16462733 DOI: 10.1038/ncb1372 URL: http://europepmc.org/abstract/med/16462733 2005 Kaiso-deficient mice show resistance to intestinal cancer. Journal: Molecular and cellular biology Published: 31/12/2005 PMID: 16354691 PMC: PMC1317619 DOI: 10.1128/MCB.26.1.199-208.2006 URL: http://europepmc.org/abstract/med/16354691 Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity. Journal: Journal of immunology (Baltimore, Md. : 1950) Published: 31/10/2005 PMID: 16237047 DOI: 10.4049/jimmunol.175.9.5606 URL: http://europepmc.org/abstract/med/16237047 MeCP2 in neurons: closing in on the causes of Rett syndrome. Journal: Human molecular genetics Published: 31/03/2005 PMID: 15809268 DOI: 10.1093/hmg/ddi102 URL: http://europepmc.org/abstract/med/15809268 2003 Deficiency of Mbd2 suppresses intestinal tumorigenesis. Journal: Nature genetics Published: 31/05/2003 PMID: 12730693 DOI: 10.1038/ng1155 URL: http://europepmc.org/abstract/med/12730693 The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Journal: Trends in genetics : TIG Published: 30/04/2003 PMID: 12711219 DOI: 10.1016/s0168-9525(03)00080-5 URL: http://europepmc.org/abstract/med/12711219 2002 Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs? Journal: Oncogene Published: 31/07/2002 PMID: 12154402 DOI: 10.1038/sj.onc.1205631 URL: http://europepmc.org/abstract/med/12154402 Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Journal: Science (New York, N.Y.) Published: 30/06/2002 PMID: 12130785 DOI: 10.1126/science.1073354 URL: http://europepmc.org/abstract/med/12130785 Gene silencing quantitatively controls the function of a developmental trans-activator. Journal: Molecular cell Published: 30/06/2002 PMID: 12150909 DOI: 10.1016/s1097-2765(02)00564-6 URL: http://europepmc.org/abstract/med/12150909 2001 Dynamic reprogramming of DNA methylation in the early mouse embryo. Journal: Developmental biology Published: 31/12/2001 PMID: 11784103 DOI: 10.1006/dbio.2001.0501 URL: http://europepmc.org/abstract/med/11784103 Epigenetic reprogramming: how now, cloned cow? Journal: Current biology : CB Published: 31/12/2001 PMID: 11818083 DOI: 10.1016/s0960-9822(01)00677-7 URL: http://europepmc.org/abstract/med/11818083 Human diseases with underlying defects in chromatin structure and modification. Journal: Human molecular genetics Published: 30/09/2001 PMID: 11673406 DOI: 10.1093/hmg/10.20.2233 URL: http://europepmc.org/abstract/med/11673406 The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Journal: Genes & development Published: 30/06/2001 PMID: 11445535 PMC: PMC312733 DOI: 10.1101/gad.198501 URL: http://europepmc.org/abstract/med/11445535 A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Journal: Nature genetics Published: 28/02/2001 PMID: 11242117 DOI: 10.1038/85899 URL: http://europepmc.org/abstract/med/11242117 Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Journal: Genes & development Published: 28/02/2001 PMID: 11274056 PMC: PMC312657 DOI: 10.1101/gad.194101 URL: http://europepmc.org/abstract/med/11274056 1999 Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylation. Journal: Current topics in microbiology and immunology Published: 31/12/1999 PMID: 10802938 URL: http://europepmc.org/abstract/med/10802938 Methylation moves into medicine. Journal: Current biology : CB Published: 31/12/1999 PMID: 10662663 DOI: 10.1016/s0960-9822(00)00286-4 URL: http://europepmc.org/abstract/med/10662663 Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. Journal: Oncogene Published: 30/11/1999 PMID: 10637515 DOI: 10.1038/sj.onc.1203229 URL: http://europepmc.org/abstract/med/10637515 Vestiges of a DNA methylation system in Drosophila melanogaster? Journal: Nature genetics Published: 30/11/1999 PMID: 10581020 DOI: 10.1038/70490 URL: http://europepmc.org/abstract/med/10581020 Breaking the silence in Rett syndrome. Journal: Nature genetics Published: 30/09/1999 PMID: 10508498 DOI: 10.1038/13751 URL: http://europepmc.org/abstract/med/10508498 Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Journal: Mammalian genome : official journal of the International Mammalian Genome Society Published: 31/08/1999 PMID: 10441743 DOI: 10.1007/s003359901112 URL: http://europepmc.org/abstract/med/10441743 MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Journal: Nature genetics Published: 31/08/1999 PMID: 10471499 DOI: 10.1038/12659 URL: http://europepmc.org/abstract/med/10471499 The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Journal: Nature Published: 31/08/1999 PMID: 10499592 DOI: 10.1038/45843 URL: http://europepmc.org/abstract/med/10499592 1998 Identification and characterization of a family of mammalian methyl-CpG binding proteins. Journal: Molecular and cellular biology Published: 31/10/1998 PMID: 9774669 PMC: PMC109239 DOI: 10.1128/mcb.18.11.6538 URL: http://europepmc.org/abstract/med/9774669 1997 A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation. Journal: Nature genetics Published: 31/10/1997 PMID: 9354806 DOI: 10.1038/ng1197-353 URL: http://europepmc.org/abstract/med/9354806 Identification and characterization of the human XIST gene promoter: implications for models of X chromosome inactivation. Journal: Nucleic acids research Published: 30/06/1997 PMID: 9185579 PMC: PMC146792 DOI: 10.1093/nar/25.13.2661 URL: http://europepmc.org/abstract/med/9185579 1994 Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals. Journal: Human molecular genetics Published: 31/12/1994 PMID: 8541877 DOI: 10.1093/hmg/4.suppl_1.1765 URL: http://europepmc.org/abstract/med/8541877 1993 Evolutionary conservation of possible functional domains of the human and murine XIST genes. Journal: Human molecular genetics Published: 31/05/1993 PMID: 8353487 DOI: 10.1093/hmg/2.6.663 URL: http://europepmc.org/abstract/med/8353487 1992 Epigenetic and chromosomal control of gene expression: molecular and genetic analysis of X chromosome inactivation. Journal: Cold Spring Harbor symposia on quantitative biology Published: 31/12/1992 PMID: 7956044 DOI: 10.1101/sqb.1993.058.01.037 URL: http://europepmc.org/abstract/med/7956044 The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Journal: Cell Published: 30/09/1992 PMID: 1423611 DOI: 10.1016/0092-8674(92)90520-m URL: http://europepmc.org/abstract/med/1423611