Prof Soojin Ryu Mireille Gillings Professor of Neurobiology S.Ryu@exeter.ac.uk CMH Groups: Ryu Group University profile 0000-0002-7059-0160 Publications Publications 2024 Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload Journal: Journal of Experimental Biology Published: 07/03/2024 DOI: 10.1242/jeb.246128 URL: https://doi.org/10.1242/jeb.246128 2023 Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse Journal: Proceedings of the National Academy of Sciences Published: 25/04/2023 DOI: 10.1073/pnas.2205576120 URL: https://doi.org/10.1073/pnas.2205576120 Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse Journal: Proceedings of the National Academy of Sciences Published: 25/04/2023 DOI: 10.1073/pnas.2205576120 URL: https://doi.org/10.1073/pnas.2205576120 Developmental Glucocorticoid exposure in zebrafish primes expression of genes linked to human psychiatric disorders Published: 14/02/2023 DOI: 10.1101/2023.02.13.528363 URL: https://doi.org/10.1101/2023.02.13.528363 Developmental Glucocorticoid exposure in zebrafish alters adult behavior and primes differential expression of genes linked to human psychiatric disorders Published: 14/02/2023 DOI: 10.1101/2023.02.13.528363 URL: https://doi.org/10.1101/2023.02.13.528363 Elevated glucocorticoid exposure during development alters behaviors and primes transcriptional responses to stress in adult zebrafish Published: 14/02/2023 DOI: 10.1101/2023.02.13.528363 URL: https://doi.org/10.1101/2023.02.13.528363 Lifelong molecular consequences of high Glucocorticoids exposure during development Published: 14/02/2023 DOI: 10.1101/2023.02.13.528363 URL: https://doi.org/10.1101/2023.02.13.528363 Acute stress modulates social approach and social maintenance in adult zebrafish Published: 12/02/2023 DOI: 10.1101/2023.02.10.528021 URL: https://doi.org/10.1101/2023.02.10.528021 Elevated Glucocorticoid alters the trajectory of hypothalamic development and function Published: 27/01/2023 DOI: 10.1101/2023.01.27.525966 URL: https://doi.org/10.1101/2023.01.27.525966 Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish Published: 27/01/2023 DOI: 10.1101/2023.01.27.525966 URL: https://doi.org/10.1101/2023.01.27.525966 2021 The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish Published: 28/07/2021 DOI: 10.1101/2021.07.28.454115 URL: https://doi.org/10.1101/2021.07.28.454115 Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio) Published: 27/06/2021 DOI: 10.1101/2021.06.26.449566 URL: https://doi.org/10.1101/2021.06.26.449566 2020 The neuropeptide Pth2 dynamically senses others via mechanosensation. Journal: Nature Published: 02/12/2020 PMID: 33268890 DOI: 10.1038/s41586-020-2988-z URL: https://doi.org/10.1038/s41586-020-2988-z Reconceptualising resilience within a translational framework is supported by unique and brain-region specific transcriptional signatures in mice Published: 16/11/2020 DOI: 10.1101/2020.11.15.383489 URL: https://doi.org/10.1101/2020.11.15.383489 2019 Active behaviour during early development shapes glucocorticoid reactivity. Journal: Scientific reports Published: 05/09/2019 PMID: 31488853 PMC: PMC6728389 DOI: 10.1038/s41598-019-49388-3 URL: https://europepmc.org/articles/PMC6728389 Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge. Journal: Proteomics Published: 01/07/2019 PMID: 31168896 DOI: 10.1002/pmic.201900028 URL: https://doi.org/10.1002/pmic.201900028 2018 Understanding and Predicting Antidepressant Response: Using Animal Models to Move Toward Precision Psychiatry. Journal: Frontiers in psychiatry Published: 22/10/2018 PMID: 30405454 PMC: PMC6204461 DOI: 10.3389/fpsyt.2018.00512 URL: https://europepmc.org/articles/PMC6204461 Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish. Journal: Cell and tissue research Published: 14/08/2018 PMID: 30109407 DOI: 10.1007/s00441-018-2900-4 URL: https://doi.org/10.1007/s00441-018-2900-4 2017 Optogenetic interpellation of behavior employing unrestrained zebrafish larvae Journal: A Roadmap for Optogenetics Published: 25/10/2017 URL: Performance on innate behaviour during early development as a function of stress level. Journal: Scientific reports Published: 10/08/2017 PMID: 28798473 PMC: PMC5552790 DOI: 10.1038/s41598-017-08400-4 URL: https://europepmc.org/articles/PMC5552790 Identification of accessory olfactory system and medial amygdala in the zebrafish. Journal: Scientific reports Published: 14/03/2017 PMID: 28290515 PMC: PMC5349599 DOI: 10.1038/srep44295 URL: https://europepmc.org/articles/PMC5349599 Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Journal: Current biology : CB Published: 05/01/2017 PMID: 28065605 DOI: 10.1016/j.cub.2016.11.038 URL: https://doi.org/10.1016/j.cub.2016.11.038 Single-Cell Reconstruction of Oxytocinergic Neurons Reveals Separate Hypophysiotropic and Encephalotropic Subtypes in Larval Zebrafish. Journal: eNeuro Published: 01/01/2017 PMID: 28317020 PMC: PMC5356222 DOI: 10.1523/eneuro.0278-16.2016 URL: https://europepmc.org/articles/PMC5356222 2016 iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins. Journal: Development (Cambridge, England) Published: 05/10/2016 PMID: 27707796 PMC: PMC5117216 DOI: 10.1242/dev.139261 URL: https://europepmc.org/articles/PMC5117216 Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Journal: Nature communications Published: 20/09/2016 PMID: 27646867 PMC: PMC5034294 DOI: 10.1038/ncomms12620 URL: https://europepmc.org/articles/PMC5034294 The Severity of Acute Stress Is Represented by Increased Synchronous Activity and Recruitment of Hypothalamic CRH Neurons. Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience Published: 01/03/2016 PMID: 26985042 PMC: PMC6705521 DOI: 10.1523/jneurosci.3390-15.2016 URL: https://europepmc.org/articles/PMC6705521 2015 Manipulation of Interrenal Cell Function in Developing Zebrafish Using Genetically Targeted Ablation and an Optogenetic Tool. Journal: Endocrinology Published: 01/07/2015 PMID: 26132917 DOI: 10.1210/en.2015-1021 URL: https://doi.org/10.1210/EN.2015-1021 Positive taxis and sustained responsiveness to water motions in larval zebrafish. Journal: Frontiers in neural circuits Published: 06/03/2015 PMID: 25798089 PMC: PMC4351627 DOI: 10.3389/fncir.2015.00009 URL: https://europepmc.org/articles/PMC4351627 Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish. Journal: Frontiers in neuroanatomy Published: 12/02/2015 PMID: 25729355 PMC: PMC4325906 DOI: 10.3389/fnana.2015.00002 URL: https://europepmc.org/articles/PMC4325906 2014 A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response. Journal: BMC developmental biology Published: 27/11/2014 PMID: 25427861 PMC: PMC4248439 DOI: 10.1186/s12861-014-0041-x URL: https://europepmc.org/articles/PMC4248439 The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development. Journal: Frontiers in behavioral neuroscience Published: 20/10/2014 PMID: 25368561 PMC: PMC4202704 DOI: 10.3389/fnbeh.2014.00367 URL: https://europepmc.org/articles/PMC4202704 Classification of object size in retinotectal microcircuits. Journal: Current biology : CB Published: 18/09/2014 PMID: 25242030 DOI: 10.1016/j.cub.2014.09.012 URL: https://doi.org/10.1016/j.cub.2014.09.012 Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 02/06/2014 PMID: 24889611 PMC: PMC4066486 DOI: 10.1073/pnas.1321600111 URL: https://europepmc.org/articles/PMC4066486 Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. Journal: The Journal of comparative neurology Published: 01/05/2014 PMID: 24127437 DOI: 10.1002/cne.23480 URL: https://doi.org/10.1002/cne.23480 2013 An optimized whole-body cortisol quantification method for assessing stress levels in larval zebrafish. Journal: PloS one Published: 01/11/2013 PMID: 24223943 PMC: PMC3815139 DOI: 10.1371/journal.pone.0079406 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223943/?tool=EBI Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish. Journal: Frontiers in neural circuits Published: 06/05/2013 PMID: 23653595 PMC: PMC3644639 DOI: 10.3389/fncir.2013.00082 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23653595/?tool=EBI Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Journal: Development (Cambridge, England) Published: 01/04/2013 PMID: 23533176 DOI: 10.1242/dev.085357 URL: https://doi.org/10.1242/dev.085357 2012 Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum. Journal: Neuron Published: 01/12/2012 PMID: 23259950 DOI: 10.1016/j.neuron.2012.12.003 URL: https://doi.org/10.1016/j.neuron.2012.12.003 Habenula circuit development: past, present, and future. Journal: Frontiers in neuroscience Published: 23/04/2012 PMID: 22536170 PMC: PMC3332237 DOI: 10.3389/fnins.2012.00051 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536170/?tool=EBI 2011 Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems. Journal: Nature communications Published: 01/01/2011 PMID: 21266970 PMC: PMC3105308 DOI: 10.1038/ncomms1171 URL: https://europepmc.org/articles/PMC3105308 2010 Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish. Journal: The Journal of comparative neurology Published: 01/02/2010 PMID: 20017210 PMC: PMC2841826 DOI: 10.1002/cne.22214 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20017210/?tool=EBI 2009 Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages. Journal: Development (Cambridge, England) Published: 01/03/2009 PMID: 19234064 DOI: 10.1242/dev.033878 URL: https://doi.org/10.1242/dev.033878 2008 Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven green fluorescent protein transgenic zebrafish. Journal: Molecular vision Published: 26/12/2008 PMID: 19112533 PMC: PMC2610293 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19112533/?tool=EBI 2007 Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development. Journal: BMC developmental biology Published: 05/12/2007 PMID: 18053265 PMC: PMC2217549 DOI: 10.1186/1471-213x-7-135 URL: https://europepmc.org/articles/PMC2217549 Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Journal: Current biology : CB Published: 03/05/2007 PMID: 17481897 DOI: 10.1016/j.cub.2007.04.003 URL: https://doi.org/10.1016/j.cub.2007.04.003 Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4. Journal: Human molecular genetics Published: 03/05/2007 PMID: 17478476 DOI: 10.1093/hmg/ddm099 URL: https://doi.org/10.1093/hmg/ddm099 2006 her5 expression reveals a pool of neural stem cells in the adult zebrafish midbrain. Journal: Development (Cambridge, England) Published: 01/11/2006 PMID: 17038515 DOI: 10.1242/dev.02573 URL: https://doi.org/10.1242/dev.02573 Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis. Journal: Cell cycle (Georgetown, Tex.) Published: 01/06/2006 PMID: 16721065 DOI: 10.4161/cc.5.11.2779 URL: https://doi.org/10.4161/cc.5.11.2779 Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development. Journal: Genetics Published: 02/04/2006 PMID: 16582438 PMC: PMC1602071 DOI: 10.1534/genetics.105.055152 URL: https://europepmc.org/articles/PMC1602071 Genetic analysis of dopaminergic system development in zebrafish. Journal: Journal of neural transmission. Supplementum Published: 01/01/2006 PMID: 17017510 DOI: 10.1007/978-3-211-45295-0_11 URL: https://doi.org/10.1007/978-3-211-45295-0_11 2005 Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis. Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 08/12/2005 PMID: 16339308 PMC: PMC1317923 DOI: 10.1073/pnas.0506187102 URL: https://europepmc.org/articles/PMC1317923 2001 Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Journal: Mechanisms of development Published: 01/03/2001 PMID: 11231083 DOI: 10.1016/s0925-4773(01)00287-8 URL: https://doi.org/10.1016/s0925-4773(01)00287-8 1999 Purification of transcription cofactor complex CRSP. Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 01/06/1999 PMID: 10377381 PMC: PMC22029 DOI: 10.1073/pnas.96.13.7137 URL: https://europepmc.org/articles/PMC22029 The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Journal: Nature Published: 01/02/1999 PMID: 9989412 DOI: 10.1038/17141 URL: https://doi.org/10.1038/17141 1998 Cofactor requirements for transcriptional activation by Sp1. Journal: Cold Spring Harbor Symposia of Quantitative Biology: Mechanisms of Transcription Published: 01/01/1998 PMID: 10384283 DOI: 10.1101/sqb.1998.63.189 URL: https://doi.org/10.1101/sqb.1998.63.189