Prof Soojin Ryu

Mireille Gillings Professor of Neurobiology

S.Ryu@exeter.ac.uk

CMH

Groups: Ryu Group

University profile

0000-0002-7059-0160

Publications

2023

Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse

Journal: Proceedings of the National Academy of Sciences

Published: 25/04/2023
DOI: 10.1073/pnas.2205576120
URL: https://doi.org/10.1073/pnas.2205576120

Fear circuit–based neurobehavioral signatures mirror resilience to chronic social stress in mouse

Journal: Proceedings of the National Academy of Sciences

Published: 25/04/2023
DOI: 10.1073/pnas.2205576120
URL: https://doi.org/10.1073/pnas.2205576120

Developmental Glucocorticoid exposure in zebrafish primes expression of genes linked to human psychiatric disorders

Published: 14/02/2023
DOI: 10.1101/2023.02.13.528363
URL: https://doi.org/10.1101/2023.02.13.528363

Developmental Glucocorticoid exposure in zebrafish alters adult behavior and primes differential expression of genes linked to human psychiatric disorders

Published: 14/02/2023
DOI: 10.1101/2023.02.13.528363
URL: https://doi.org/10.1101/2023.02.13.528363

Elevated glucocorticoid exposure during development alters behaviors and primes transcriptional responses to stress in adult zebrafish

Published: 14/02/2023
DOI: 10.1101/2023.02.13.528363
URL: https://doi.org/10.1101/2023.02.13.528363

Acute stress modulates social approach and social maintenance in adult zebrafish

Published: 12/02/2023
DOI: 10.1101/2023.02.10.528021
URL: https://doi.org/10.1101/2023.02.10.528021

Elevated Glucocorticoid alters the trajectory of hypothalamic development and function

Published: 27/01/2023
DOI: 10.1101/2023.01.27.525966
URL: https://doi.org/10.1101/2023.01.27.525966

Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish

Published: 27/01/2023
DOI: 10.1101/2023.01.27.525966
URL: https://doi.org/10.1101/2023.01.27.525966

2021

The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish

Published: 28/07/2021
DOI: 10.1101/2021.07.28.454115
URL: https://doi.org/10.1101/2021.07.28.454115

Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio)

Published: 27/06/2021
DOI: 10.1101/2021.06.26.449566
URL: https://doi.org/10.1101/2021.06.26.449566

2020

The neuropeptide Pth2 dynamically senses others via mechanosensation.

Journal: Nature

Published: 02/12/2020
PMID: 33268890
DOI: 10.1038/s41586-020-2988-z
URL: https://doi.org/10.1038/s41586-020-2988-z

Reconceptualising resilience within a translational framework is supported by unique and brain-region specific transcriptional signatures in mice

Published: 16/11/2020
DOI: 10.1101/2020.11.15.383489
URL: https://doi.org/10.1101/2020.11.15.383489

2019

Active behaviour during early development shapes glucocorticoid reactivity.

Journal: Scientific reports

Published: 05/09/2019
PMID: 31488853
PMC: PMC6728389
DOI: 10.1038/s41598-019-49388-3
URL: https://europepmc.org/articles/PMC6728389

Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge.

Journal: Proteomics

Published: 01/07/2019
PMID: 31168896
DOI: 10.1002/pmic.201900028
URL: https://doi.org/10.1002/pmic.201900028

2018

Understanding and Predicting Antidepressant Response: Using Animal Models to Move Toward Precision Psychiatry.

Journal: Frontiers in psychiatry

Published: 22/10/2018
PMID: 30405454
PMC: PMC6204461
DOI: 10.3389/fpsyt.2018.00512
URL: https://europepmc.org/articles/PMC6204461

Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish.

Journal: Cell and tissue research

Published: 14/08/2018
PMID: 30109407
DOI: 10.1007/s00441-018-2900-4
URL: https://doi.org/10.1007/s00441-018-2900-4

2017

Optogenetic interpellation of behavior employing unrestrained zebrafish larvae

Journal: A Roadmap for Optogenetics

Published: 25/10/2017
URL:

Performance on innate behaviour during early development as a function of stress level.

Journal: Scientific reports

Published: 10/08/2017
PMID: 28798473
PMC: PMC5552790
DOI: 10.1038/s41598-017-08400-4
URL: https://europepmc.org/articles/PMC5552790

Identification of accessory olfactory system and medial amygdala in the zebrafish.

Journal: Scientific reports

Published: 14/03/2017
PMID: 28290515
PMC: PMC5349599
DOI: 10.1038/srep44295
URL: https://europepmc.org/articles/PMC5349599

Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting.

Journal: Current biology : CB

Published: 05/01/2017
PMID: 28065605
DOI: 10.1016/j.cub.2016.11.038
URL: https://doi.org/10.1016/j.cub.2016.11.038

Single-Cell Reconstruction of Oxytocinergic Neurons Reveals Separate Hypophysiotropic and Encephalotropic Subtypes in Larval Zebrafish.

Journal: eNeuro

Published: 01/01/2017
PMID: 28317020
PMC: PMC5356222
DOI: 10.1523/eneuro.0278-16.2016
URL: https://europepmc.org/articles/PMC5356222

2016

iDamIDseq and iDEAR: an improved method and computational pipeline to profile chromatin-binding proteins.

Journal: Development (Cambridge, England)

Published: 05/10/2016
PMID: 27707796
PMC: PMC5117216
DOI: 10.1242/dev.139261
URL: https://europepmc.org/articles/PMC5117216

Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour.

Journal: Nature communications

Published: 20/09/2016
PMID: 27646867
PMC: PMC5034294
DOI: 10.1038/ncomms12620
URL: https://europepmc.org/articles/PMC5034294

The Severity of Acute Stress Is Represented by Increased Synchronous Activity and Recruitment of Hypothalamic CRH Neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience

Published: 01/03/2016
PMID: 26985042
PMC: PMC6705521
DOI: 10.1523/jneurosci.3390-15.2016
URL: https://europepmc.org/articles/PMC6705521

2015

Manipulation of Interrenal Cell Function in Developing Zebrafish Using Genetically Targeted Ablation and an Optogenetic Tool.

Journal: Endocrinology

Published: 01/07/2015
PMID: 26132917
DOI: 10.1210/en.2015-1021
URL: https://doi.org/10.1210/EN.2015-1021

Positive taxis and sustained responsiveness to water motions in larval zebrafish.

Journal: Frontiers in neural circuits

Published: 06/03/2015
PMID: 25798089
PMC: PMC4351627
DOI: 10.3389/fncir.2015.00009
URL: https://europepmc.org/articles/PMC4351627

Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish.

Journal: Frontiers in neuroanatomy

Published: 12/02/2015
PMID: 25729355
PMC: PMC4325906
DOI: 10.3389/fnana.2015.00002
URL: https://europepmc.org/articles/PMC4325906

2014

A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response.

Journal: BMC developmental biology

Published: 27/11/2014
PMID: 25427861
PMC: PMC4248439
DOI: 10.1186/s12861-014-0041-x
URL: https://europepmc.org/articles/PMC4248439

The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development.

Journal: Frontiers in behavioral neuroscience

Published: 20/10/2014
PMID: 25368561
PMC: PMC4202704
DOI: 10.3389/fnbeh.2014.00367
URL: https://europepmc.org/articles/PMC4202704

Classification of object size in retinotectal microcircuits.

Journal: Current biology : CB

Published: 18/09/2014
PMID: 25242030
DOI: 10.1016/j.cub.2014.09.012
URL: https://doi.org/10.1016/j.cub.2014.09.012

Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: 02/06/2014
PMID: 24889611
PMC: PMC4066486
DOI: 10.1073/pnas.1321600111
URL: https://europepmc.org/articles/PMC4066486

Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae.

Journal: The Journal of comparative neurology

Published: 01/05/2014
PMID: 24127437
DOI: 10.1002/cne.23480
URL: https://doi.org/10.1002/cne.23480

2013

An optimized whole-body cortisol quantification method for assessing stress levels in larval zebrafish.

Journal: PloS one

Published: 01/11/2013
PMID: 24223943
PMC: PMC3815139
DOI: 10.1371/journal.pone.0079406
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223943/?tool=EBI

Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish.

Journal: Frontiers in neural circuits

Published: 06/05/2013
PMID: 23653595
PMC: PMC3644639
DOI: 10.3389/fncir.2013.00082
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23653595/?tool=EBI

Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2.

Journal: Development (Cambridge, England)

Published: 01/04/2013
PMID: 23533176
DOI: 10.1242/dev.085357
URL: https://doi.org/10.1242/dev.085357

2012

Layer-specific targeting of direction-selective neurons in the zebrafish optic tectum.

Journal: Neuron

Published: 01/12/2012
PMID: 23259950
DOI: 10.1016/j.neuron.2012.12.003
URL: https://doi.org/10.1016/j.neuron.2012.12.003

Habenula circuit development: past, present, and future.

Journal: Frontiers in neuroscience

Published: 23/04/2012
PMID: 22536170
PMC: PMC3332237
DOI: 10.3389/fnins.2012.00051
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536170/?tool=EBI

2011

Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems.

Journal: Nature communications

Published: 01/01/2011
PMID: 21266970
PMC: PMC3105308
DOI: 10.1038/ncomms1171
URL: https://europepmc.org/articles/PMC3105308

2010

Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish.

Journal: The Journal of comparative neurology

Published: 01/02/2010
PMID: 20017210
PMC: PMC2841826
DOI: 10.1002/cne.22214
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20017210/?tool=EBI

2009

Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages.

Journal: Development (Cambridge, England)

Published: 01/03/2009
PMID: 19234064
DOI: 10.1242/dev.033878
URL: https://doi.org/10.1242/dev.033878

2008

Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven green fluorescent protein transgenic zebrafish.

Journal: Molecular vision

Published: 26/12/2008
PMID: 19112533
PMC: PMC2610293
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19112533/?tool=EBI

2007

Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development.

Journal: BMC developmental biology

Published: 05/12/2007
PMID: 18053265
PMC: PMC2217549
DOI: 10.1186/1471-213x-7-135
URL: https://europepmc.org/articles/PMC2217549

Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.

Journal: Current biology : CB

Published: 03/05/2007
PMID: 17481897
DOI: 10.1016/j.cub.2007.04.003
URL: https://doi.org/10.1016/j.cub.2007.04.003

Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4.

Journal: Human molecular genetics

Published: 03/05/2007
PMID: 17478476
DOI: 10.1093/hmg/ddm099
URL: https://doi.org/10.1093/hmg/ddm099

2006

her5 expression reveals a pool of neural stem cells in the adult zebrafish midbrain.

Journal: Development (Cambridge, England)

Published: 01/11/2006
PMID: 17038515
DOI: 10.1242/dev.02573
URL: https://doi.org/10.1242/dev.02573

Minichromosome maintenance proteins as markers for proliferation zones during embryogenesis.

Journal: Cell cycle (Georgetown, Tex.)

Published: 01/06/2006
PMID: 16721065
DOI: 10.4161/cc.5.11.2779
URL: https://doi.org/10.4161/cc.5.11.2779

Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development.

Journal: Genetics

Published: 02/04/2006
PMID: 16582438
PMC: PMC1602071
DOI: 10.1534/genetics.105.055152
URL: https://europepmc.org/articles/PMC1602071

Genetic analysis of dopaminergic system development in zebrafish.

Journal: Journal of neural transmission. Supplementum

Published: 01/01/2006
PMID: 17017510
DOI: 10.1007/978-3-211-45295-0_11
URL: https://doi.org/10.1007/978-3-211-45295-0_11

2005

Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: 08/12/2005
PMID: 16339308
PMC: PMC1317923
DOI: 10.1073/pnas.0506187102
URL: https://europepmc.org/articles/PMC1317923

2001

Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo.

Journal: Mechanisms of development

Published: 01/03/2001
PMID: 11231083
DOI: 10.1016/s0925-4773(01)00287-8
URL: https://doi.org/10.1016/s0925-4773(01)00287-8

1999

Purification of transcription cofactor complex CRSP.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: 01/06/1999
PMID: 10377381
PMC: PMC22029
DOI: 10.1073/pnas.96.13.7137
URL: https://europepmc.org/articles/PMC22029

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.

Journal: Nature

Published: 01/02/1999
PMID: 9989412
DOI: 10.1038/17141
URL: https://doi.org/10.1038/17141

1998

Cofactor requirements for transcriptional activation by Sp1.

Journal: Cold Spring Harbor Symposia of Quantitative Biology: Mechanisms of Transcription

Published: 01/01/1998
PMID: 10384283
DOI: 10.1101/sqb.1998.63.189
URL: https://doi.org/10.1101/sqb.1998.63.189