Harmer Group

Interdisciplinary PhD position available: Time-resolved enzyme structural studies

Imaging proteins in the act of catalysis is a key goal for modern structural biology. In this project, you will learn the methods for preparing proteins for structural analysis and help to develop methods to determine protein-substrate structures during enzyme catalysis. At the conclusion of the project, you will have a strong education in a wide range of methods for modern structural biology and in molecular enzymology.
This project will be a collaboration with Diamond Light Source and a key opportunity of the project will be working with team members and Diamond to help develop methods at the cutting edge of structural biology. The University of Exeter has a strong structural biology group who will support you in data processing and using bioinformatics (e.g. AlphaFold) to support structural work.
The project will offer a challenging and interdisciplinary PhD in cutting-edge research areas. All the methods are well established in the supervisor’s group and their collaborators. There will be opportunities to also learn associated methods that the laboratories specialise in as the project develops.

See the group website https://www.exeter.ac.uk/research/livingsystems/team/profile/index.php?web_id=nic_harmer