
Publications
2023
The ROK kinase N-acetylglucosamine kinase uses a sequential random enzyme mechanism with successive conformational changes upon each substrate binding
Journal:
Journal of Biological Chemistry
Published:
31/03/2023
DOI: 10.1016/j.jbc.2023.103033
URL: https://doi.org/10.1016/j.jbc.2023.103033
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei
Journal:
SLAS Discovery
Published:
28/02/2023
DOI: 10.1016/j.slasd.2023.03.004
URL: https://doi.org/10.1016/j.slasd.2023.03.004
2022
Survivor bias drives overestimation of stability in reconstructed ancestral proteins
Published: 25/11/2022DOI: 10.1101/2022.11.23.517659
URL: https://doi.org/10.1101/2022.11.23.517659
Towards Elucidating the Rotary Mechanism of the Archaellum Machinery
Journal:
Frontiers in Microbiology
Published:
21/03/2022
DOI: 10.3389/fmicb.2022.848597
ISSN: 1664-302X
URL: http://dx.doi.org/10.3389/fmicb.2022.848597
Pseudomonas aeruginosa Biofilm Dispersion by the Human Atrial Natriuretic Peptide
Journal:
Advanced Science
Published:
28/02/2022
DOI: 10.1002/advs.202103262
URL: https://doi.org/10.1002/advs.202103262
2021
Unique Data Sets and Bespoke Laboratory Videos: Teaching and Assessing of Experimental Methods and Data Analysis in a Pandemic
Journal:
Journal of Chemical Education
Published:
14/12/2021
DOI: 10.1021/acs.jchemed.1c00853
URL: https://doi.org/10.1021/acs.jchemed.1c00853
Structure and function of N-acetylglucosamine kinase illuminates the catalytic mechanism of ROK kinases
Published: 30/09/2021DOI: 10.1101/2021.09.30.462564
URL: https://doi.org/10.1101/2021.09.30.462564
Heterologous Protein Expression Favors the Formation of Protein Aggregates in Persister and Viable but Nonculturable Bacteria.
Journal:
ACS Infectious Diseases
Published:
11/06/2021
DOI: 10.1021/acsinfecdis.1c00154
URL: https://doi.org/10.1021/acsinfecdis.1c00154
Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species
Journal:
PLOS ONE
Published:
25/03/2021
DOI: 10.1371/journal.pone.0248119
URL: https://doi.org/10.1371/journal.pone.0248119
2020
Special Issue on the 60th anniversary of the first laser—Series I: Microcavity Photonics—from fundamentals to applications
Journal:
Light: Science and Applications
Published:
30/11/2020
DOI: 10.1038/s41377-021-00583-w
EID: 2-s2.0-85109707384
ISSN: 20477538 20955545
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-85109707384&partnerID=MN8TOARS
Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases
Journal:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Published:
31/01/2020
DOI: 10.1016/j.bbapap.2019.140322
URL: https://doi.org/10.1016/j.bbapap.2019.140322
2019
Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction
Journal:
Communications Biology
Published:
22/11/2019
DOI: 10.1038/s42003-019-0677-y
URL: https://doi.org/10.1038/s42003-019-0677-y
Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile
Journal:
Journal of Biological Chemistry
Published:
30/09/2019
DOI: 10.1074/jbc.RA119.010120
URL: https://doi.org/10.1074/jbc.RA119.010120
Engineering a Seven Enzyme Biotransformation using Mathematical Modelling and Characterized Enzyme Parts
Journal:
ChemCatChem
Published:
07/08/2019
DOI: 10.1002/cctc.201900646
URL: https://doi.org/10.1002/cctc.201900646
Drug screening to identify compounds to act as co-therapies for the treatment of pathogenic Burkholderia
Published: 08/07/2019DOI: 10.1101/692129
URL: https://doi.org/10.1101/692129
A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity
Published: 13/02/2019DOI: 10.1101/548628
URL: https://doi.org/10.1101/548628
2018
Carbohydrate Kinases: A Conserved Mechanism Across Differing Folds
Journal:
Catalysts
Published:
31/12/2018
DOI: 10.3390/catal9010029
URL: http://www.mdpi.com/2073-4344/9/1/29
Pair creation, motion, and annihilation of topological defects in two-dimensional nematic liquid crystals
Journal:
Physical Review E
Published:
31/01/2018
DOI: 10.1103/physreve.97.022704
ISSN: 2470-0045
URL:
2017
A half-site multimeric enzyme achieves its cooperativity without conformational changes
Journal:
Scientific Reports
Published:
28/11/2017
DOI: 10.1038/s41598-017-16421-2
URL: https://doi.org/10.1038/s41598-017-16421-2
Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry
Journal:
ChemCatChem
Published:
20/03/2017
DOI: 10.1002/cctc.201601249
URL:
2014
Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors
Published: 30/11/2014DOI: 10.1016/j.pbiomolbio.2015.04.007
URL:
Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation
Published: 30/11/2014DOI: 10.1128/mBio.01033-15
URL:
Unravelling the B. pseudomallei heptokinase WcbL: from Structure to Drug Discovery
Journal:
Chemistry & Biology
Published:
30/11/2014
DOI: 10.1016/j.chembiol.2015.10.015
URL:
2013
A structural biology approach enables to development of antimicrobials targeting bacterial immunophilins
Journal:
Antimicrobial Agents and Chemotherapy
Published:
30/11/2013
DOI: 10.1128/AAC.01875-13
URL:
Determination of protein-ligand interactions using differential scanning fluorimetry
Published: 30/11/2013DOI: 10.3791/51809
URL:
Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme
Journal:
IUCrJ
Published:
30/11/2013
DOI: 10.1107/S205225251302695X
URL:
The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation
Journal:
Biochemical Journal
Published:
30/11/2013
DOI: 10.1042/BJ20140073
URL:
2012
Identification of type II toxin-antitoxin modules inBurkholderia pseudomallei
Published: 30/11/2012ISSN: 0378-1097
DOI: 10.1111/1574-6968.12032
URL:
Photoinduced modification of component composition of molecular layers with silver nanoparticles
Journal:
Fundamentals of Laser-Assisted Micro- and Nanotechnologies 2013
Published:
30/11/2012
DOI: 10.1117/12.2052535
WOSUID: WOS:000333048100032
URL: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000333048100032&KeyUID=WOS:000333048100032
2011
Phosphate transporters in marine phytoplankton and their viruses: cross-domain commonalities in viral-host gene exchanges
Published: 30/11/2011DOI: 10.1111/j.1462-2920.2011.02576.x
ISSN: 1462-2912
URL:
2010
Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase
Published: 30/11/2010ISSN: 0261-4189
DOI: 10.1038/emboj.2011.361
URL:
The structure of aBurkholderia pseudomalleiimmunophilin–inhibitor complex reveals new approaches to antimicrobial development
Published: 30/11/2010ISSN: 0264-6021
DOI: 10.1042/bj20110345
URL:
2009
The Structure of Sedoheptulose-7-Phosphate Isomerase from Burkholderia pseudomallei Reveals a Zinc Binding Site at the Heart of the Active Site
Published: 30/11/2009ISSN: 0022-2836
DOI: 10.1016/j.jmb.2010.04.058
URL:
Backtracking and proofreading in DNA transcription.
Published: 31/05/2009PMID: 19659121
DOI: 10.1103/physrevlett.102.258101
URL: http://europepmc.org/abstract/med/19659121
2006
Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH fromBordetella bronchiseptica
Published: 30/11/2006DOI: 10.1107/s174430910703477x
ISSN: 1744-3091
URL:
Predicting Protein Function from Structure—The Roles of Short-chain Dehydrogenase/Reductase Enzymes in Bordetella O-antigen Biosynthesis
Published: 30/11/2006ISSN: 0022-2836
DOI: 10.1016/j.jmb.2007.09.055
URL:
2005
Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli
Published: 30/11/2005DOI: 10.1016/j.pep.2006.04.008
ISSN: 1046-5928
URL:
Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin
Published: 30/11/2005ISSN: 0264-6021
DOI: 10.1042/bj20050985
URL:
2004
1.15Å Crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family
Published: 30/11/2004ISSN: 0014-5793
DOI: 10.1016/j.febslet.2004.11.114
URL:
Role of Heparan Sulfate in Fibroblast Growth Factor Signaling
Published: 30/11/2004DOI: 10.1016/b978-008044859-6/50015-0
ISBN: 9780080448596
URL:
2003
British Society for Matrix Biology Meeting
Published: 30/11/2003ISSN: 0959-9673
DOI: 10.1111/j.0959-9673.2004.390ak.x
URL:
The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity†,‡
Published: 30/11/2003ISSN: 0006-2960
DOI: 10.1021/bi035320k
URL:
Towards a Resolution of the Stoichiometry of the Fibroblast Growth Factor (FGF)–FGF Receptor–Heparin Complex
Published: 30/11/2003ISSN: 0022-2836
DOI: 10.1016/j.jmb.2004.04.031
URL:
2002
The structural biology of growth factor receptor activation
Published: 30/11/2002ISSN: 0301-4622
DOI: 10.1016/s0301-4622(02)00305-8
URL:
2000
Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution
Published: 30/11/2000ISSN: 0014-5793
DOI: 10.1016/s0014-5793(01)02603-5
URL: