Living Systems Institute

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Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory

Journal: Proceedings of the National Academy of Sciences
Published:
URL: https://doi.org/10.1073/pnas.2109475118
LSI Authors:
Prof Austin Smith

A combined human in silico and CRISPR/Cas9-mediated in vivo zebrafish based approach for supporting gene target validation in early drug discovery

Published:
URL: https://doi.org/10.1101/2021.09.14.460241
LSI Authors:
Prof Steffen Scholpp

Protective Role of a Donepezil-Huprine Hybrid against the β-Amyloid (1-42) Effect on Human Erythrocytes

Journal: International Journal of Molecular Sciences
Published:
URL: https://doi.org/10.3390/ijms22179563
LSI Authors:
Dr Pablo Zambrano

Exploring Post-activation Conformational Changes in Pigeon Cryptochrome 4

Journal: The Journal of Physical Chemistry B
Published:
URL: https://doi.org/10.1021/acs.jpcb.1c02795
LSI Authors:
Dr Daniel Kattnig

Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment

Journal: mBio
Published:
URL: http://dx.doi.org/10.1128/mbio.00909-21
LSI Authors:
Prof Stefano Pagliara

Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published:
URL: http://europepmc.org/abstract/med/34521754
LSI Authors:
Dr Benjamin Housden

Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity

Journal: Molecular Microbiology
Published:
URL: https://doi.org/10.1111/mmi.14779
LSI Authors:
Dr Krystian Lazowski

Causal Information Rate

Journal: Entropy
Published:
URL: https://doi.org/10.3390/e23081087
LSI Authors:

Influence of the Electric Charge of Spin Probes on Their Diffusion in Room-Temperature Ionic Liquids

Journal: The Journal of Physical Chemistry B
Published:
URL: https://doi.org/10.1021/acs.jpcb.1c02493
LSI Authors:
Dr Daniel Kattnig

Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation

Journal: Bioconjugate Chemistry
Published:
URL: https://doi.org/10.1021/acs.bioconjchem.1c00286
LSI Authors:
Dr Jonathan Phillips